The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events (Q31125916)

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English	The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events	scientific article

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scholarly article

1 reference

Europe PubMed Central

13 November 2017

The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events (English)

1 reference

Europe PubMed Central

13 November 2017

author name string

Julie Craig

1

1 reference

Europe PubMed Central

13 November 2017

Irina Mikhailenko

2

1 reference

Europe PubMed Central

13 November 2017

Nathaniel Noyes

3

1 reference

Europe PubMed Central

13 November 2017

Mary Migliorini

4

1 reference

Europe PubMed Central

13 November 2017

Dudley K Strickland

5

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Europe PubMed Central

13 November 2017

language of work or name

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publication date

26 July 2013

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Europe PubMed Central

13 November 2017

1 reference

Europe PubMed Central

13 November 2017

8

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Europe PubMed Central

13 November 2017

e70432

1 reference

Europe PubMed Central

13 November 2017

7

1 reference

Europe PubMed Central

13 November 2017

copyright license

Creative Commons Attribution 4.0 International

26 July 2013

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April 2022 Public Data File from Crossref

copyright status

0 references

Vascular smooth muscle cell motility: From migration to invasion

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Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes

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21 June 2018

Low density lipoprotein receptor-related protein 1 (LRP1) forms a signaling complex with platelet-derived growth factor receptor-beta in endosomes and regulates activation of the MAPK pathway

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Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1.

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21 June 2018

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation

1 reference

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21 June 2018

Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation

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21 June 2018

Regulation of tyrosine phosphatases in the adventitia during vascular remodelling

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21 June 2018

LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies

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21 June 2018

Structural and functional consequences of tyrosine phosphorylation in the LRP1 cytoplasmic domain

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21 June 2018

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome

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Discovery of a novel shp2 protein tyrosine phosphatase inhibitor

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21 June 2018

Platelet-derived growth factor receptor-beta (PDGFR-beta) activation promotes its association with the low density lipoprotein receptor-related protein (LRP). Evidence for co-receptor function

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21 June 2018

Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta).

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21 June 2018

Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules

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Molecular regulation of vascular smooth muscle cell differentiation in development and disease

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Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.

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Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.

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v-Src induces Shc binding to tyrosine 63 in the cytoplasmic domain of the LDL receptor-related protein 1.

1 reference

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21 June 2018

LRP: role in vascular wall integrity and protection from atherosclerosis

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The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces

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Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae

1 reference

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21 June 2018

Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.

1 reference

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21 June 2018

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

1 reference

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LRP: a multifunctional scavenger and signaling receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3724782

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Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells

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Molecular mechanisms in intimal hyperplasia

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Downregulation of platelet-derived growth factor receptor-beta in Shp-2 mutant fibroblast cell lines

1 reference

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Pericyte loss and microaneurysm formation in PDGF-B-deficient mice

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Recombinant platelet-derived growth factor B gene expression in porcine arteries induce intimal hyperplasia in vivo

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The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

1 reference

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Identification of a putative Syp substrate, the PDGF beta receptor

1 reference

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Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor

1 reference

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Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew

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Protein tyrosine phosphatase SHP-2 is positively involved in platelet-derived growth factor-signaling in vascular neointima formation via the reactive oxygen species-related pathway.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070432

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1 reference

https://pubmed.ncbi.nlm.nih.gov/23922991

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Stimulated activation of platelet-derived growth factor receptor in vivo in balloon-injured arteries: a link between angiotensin II and intimal thickening

1 reference

https://pubmed.ncbi.nlm.nih.gov/23922991

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inferred from PubMed ID database lookup

PDGF receptor protein tyrosine kinase expression in the balloon-injured rat carotid artery

1 reference

https://pubmed.ncbi.nlm.nih.gov/23922991

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based on heuristic

inferred from PubMed ID database lookup

SHP-2 binds to Tyr763 and Tyr1009 in the PDGF beta-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23922991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression and function of a recombinant PDGF B gene in porcine arteries

1 reference

https://pubmed.ncbi.nlm.nih.gov/23922991

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based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/23922991

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based on heuristic

inferred from PubMed ID database lookup

Predominant expression of the src homology 2-containing tyrosine phosphatase protein SHP2 in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23922991

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0070432

1 reference

Europe PubMed Central

13 November 2017

2013PLoSO...870432C

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1 reference

Europe PubMed Central

13 November 2017

1 reference

Europe PubMed Central

13 November 2017

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