Inhibiting viral proteases: challenges and opportunities (Q31112139)

28 June 2017

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title

Inhibiting viral proteases: challenges and opportunities (English)

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28 June 2017

Elisabetta Bianchi

1

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PubMed ID

12325160

28 June 2017

Antonello Pessi

series ordinal

2

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28 June 2017

1 January 2002

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28 June 2017

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28 June 2017

66

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28 June 2017

2

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28 June 2017

101-114

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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

28 June 2017

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In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.

21 January 2018

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Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

21 January 2018

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The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

21 January 2018

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Complex formation between the hepatitis C virus serine protease and a synthetic NS4A cofactor peptide

21 January 2018

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Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping

21 January 2018

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The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism

21 January 2018

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Solution structure and dynamics of the single-chain hepatitis C virus NS3 protease NS4A cofactor complex

21 January 2018

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Conformational changes in human hepatitis C virus NS3 protease upon binding of product-based inhibitors

21 January 2018

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Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form

21 January 2018

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Converting trypsin to chymotrypsin: the role of surface loops

21 January 2018

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Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies

21 January 2018

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Role of charged residues in the catalytic mechanism of hepatitis C virus NS3 protease: electrostatic precollision guidance and transition-state stabilization

21 January 2018

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Substrate specificity of the hepatitis C virus serine protease NS3.

21 January 2018

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Designing non-peptide peptidomimetics in the 21st century: inhibitors targeting conformational ensembles.

21 January 2018

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Hepatitis C virus NS3 protease requires its NS4A cofactor peptide for optimal binding of a boronic acid inhibitor as shown by NMR.

21 January 2018

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Product inhibition of the hepatitis C virus NS3 protease

21 January 2018

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Peptide-based inhibitors of the hepatitis C virus serine protease

21 January 2018

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A glutamic acid specific serine protease utilizes a novel histidine triad in substrate binding

21 January 2018

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Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures

21 January 2018

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Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products

21 January 2018

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Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease.

21 January 2018

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The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase

21 January 2018

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A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

21 January 2018

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Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease

21 January 2018

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Evolution, synthesis and SAR of tripeptide alpha-ketoacid inhibitors of the hepatitis C virus NS3/NS4A serine protease

21 January 2018

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Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.

21 January 2018

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Inhibitor binding induces active site stabilization of the HCV NS3 protein serine protease domain

21 January 2018

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Multiple determinants influence complex formation of the hepatitis C virus NS3 protease domain with its NS4A cofactor peptide.

21 January 2018

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Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein

21 January 2018

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Solid phase synthesis of aminoboronic acids: potent inhibitors of the hepatitis C virus NS3 proteinase

21 January 2018

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Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes

21 January 2018

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Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease

21 January 2018

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Prime site binding inhibitors of a serine protease: NS3/4A of hepatitis C virus

21 January 2018

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Peptoids: a modular approach to drug discovery.

21 January 2018

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Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries

21 January 2018

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Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A

21 January 2018

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The binding energetics of first- and second-generation HIV-1 protease inhibitors: implications for drug design

21 January 2018

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Thermodynamic Basis of Resistance to HIV-1 Protease Inhibition: Calorimetric Analysis of the V82F/I84V Active Site Resistant Mutant†

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIP.10230

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28 June 2017

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PubMed ID

12325160