Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation (Q30754508)

27 September 2017

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation (English)

1 reference

27 September 2017

0 references

1 reference

14

1 reference

27 September 2017

Steven A Sloan

12

0 references

Roberta Ghidoni

object named as

Roberta Ghidoni

24

0 references

Eric J Huang

object named as

Eric J Huang

28

0 references

Barbara Borroni

23

object named as

Barbara Borroni

1 reference

27 September 2017

18

Rosa Rademakers

1 reference

27 September 2017

22

Bruce L Miller

1 reference

27 September 2017

20

William W Seeley

1 reference

27 September 2017

27

Ben A Barres

1 reference

27 September 2017

25

Robert V Farese

1 reference

27 September 2017

16

Sandra Weintraub

1 reference

27 September 2017

17

Marek-Marsel Mesulam

1 reference

27 September 2017

15

Eileen H Bigio

1 reference

27 September 2017

Hansen Lui

1

1 reference

27 September 2017

Jiasheng Zhang

2

1 reference

27 September 2017

Stefanie R Makinson

3

1 reference

27 September 2017

Michelle K Cahill

4

1 reference

27 September 2017

Kevin W Kelley

5

1 reference

27 September 2017

Hsin-Yi Huang

6

1 reference

27 September 2017

Yulei Shang

7

1 reference

27 September 2017

Michael C Oldham

8

1 reference

27 September 2017

Lauren Herl Martens

9

1 reference

27 September 2017

Fuying Gao

10

1 reference

27 September 2017

Giovanni Coppola

11

1 reference

27 September 2017

Christine L Hsieh

13

1 reference

27 September 2017

Ian R Mackenzie

19

1 reference

27 September 2017

Anna Karydas

21

1 reference

27 September 2017

Jeanne T Paz

26

1 reference

27 September 2017

language of work or name

English

0 references

publication date

20 April 2016

1 reference

27 September 2017

1 reference

27 September 2017

165

1 reference

27 September 2017

4

1 reference

27 September 2017

921-935

1 reference

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Striatal circuits, habits, and implications for obsessive-compulsive disorder.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

A dramatic increase of C1q protein in the CNS during normal aging.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Neuronal ceroid lipofuscinosis: impact of recent genetic advances and expansion of the clinicopathologic spectrum

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Microglia: scapegoat, saboteur, or something else?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Synaptic pruning by microglia is necessary for normal brain development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Microglial physiology: unique stimuli, specialized responses

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

WGCNA: an R package for weighted correlation network analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

The classical complement cascade mediates CNS synapse elimination

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

The functional organization of the barrel cortex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Immune system irregularities in lysosomal storage disorders.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

A general framework for weighted gene co-expression network analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

The prevalence of frontotemporal dementia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Complement. First of two parts

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Isolation and characterization of postsynaptic densities from various brain regions: enrichment of different types of postsynaptic densities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Serum biomarker for progranulin-associated frontotemporal lobar degeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Assays to assess autophagy induction and fusion of autophagic vacuoles with a degradative compartment, using monodansylcadaverine (MDC) and DQ-BSA.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Decreased levels of C1q in cerebrospinal fluid of living Alzheimer patients correlate with disease state

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860138

Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27114033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27114033

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2016.04.001

1 reference

27 September 2017

1 reference

27 September 2017

1 reference