Correlation and prediction of a large blood-brain distribution data set--an LFER study (Q30664006)

26 June 2017

Correlation and prediction of a large blood-brain distribution data set--an LFER study (English)

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26 June 2017

Platts JA

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26 June 2017

Abraham MH

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26 June 2017

Zhao YH

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26 June 2017

Hersey A

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26 June 2017

Ijaz L

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26 June 2017

Butina D

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26 June 2017

language of work or name

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1 September 2001

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European Journal of Medicinal Chemistry

26 June 2017

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26 June 2017

36

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26 June 2017

9

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26 June 2017

719-730

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Parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics

26 June 2017

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Measurement of brain uptake of radiolabeled substances using a tritiated water internal standard

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Molecular factors influencing drug transfer across the blood-brain barrier.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Development of a new physicochemical model for brain penetration and its application to the design of centrally acting H2 receptor histamine antagonists

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Computation of brain-blood partitioning of organic solutes via free energy calculations.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration

1 reference

https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Theoretical calculation and prediction of brain-blood partitioning of organic solutes using MolSurf parametrization and PLS statistics.

1 reference

https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Prediction of the brain-blood distribution of a large set of drugs from structurally derived descriptors using partial least-squares (PLS) modeling.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

A simple model for the prediction of blood-brain partitioning

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

High-throughput prediction of blood-brain partitioning: a thermodynamic approach

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Predicting blood-brain barrier permeation from three-dimensional molecular structure.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Estimation of molecular linear free energy relationship descriptors by a group contribution approach. 2. Prediction of partition coefficients

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Estimation of molecular linear free energy relationship descriptors. 4. Correlation and prediction of cell permeation.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Relationship between immobilised artificial membrane chromatographic retention and the brain penetration of structurally diverse drugs

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Effect of concanavalin A on the aspirin concentration and distribution in the brain and plasma of rats.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Studies on distribution and metabolism of valproate in rat brain, liver, and kidney

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Tissue distribution of ibuprofen in a fatal overdose

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Accumulation of theophylline, theobromine and paraxanthine in the fetal rat brain following a single oral dose of caffeine.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Dispositional study of opioids in mice pretreated with sympathomimetic agents

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Phosphatidylserine as a determinant for the tissue distribution of weakly basic drugs in rats.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Reevaluation of potency and pharmacokinetic properties of some lipid-soluble barbiturates with an EEG-threshold method.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Drug distribution as a function of binding competition. Experiments with the distribution dialysis technique

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Blood to brain distribution of neuroleptics

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Drug distribution between blood and brain as a determinant of antipsychotic drug effects

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Drug binding in plasma. A summary of recent trends in the study of drug and hormone binding

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Hydrogen bonding. 32. An analysis of water-octanol and water-alkane partitioning and the delta log P parameter of seiler.

1 reference

https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

Characterization of lipophilicity scales using vectors from solvation energy descriptors.

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https://api.crossref.org/works/10.1016%2FS0223-5234%2801%2901269-7

7 January 2021

10.1016/S0223-5234(01)01269-7

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DOI

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26 June 2017

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