What animal models have taught us about the treatment of acute stroke and brain protection (Q30620998)

25 June 2017

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title

What animal models have taught us about the treatment of acute stroke and brain protection (English)

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25 June 2017

Ahmed SH

1

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25 June 2017

Shaikh AY

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2

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25 June 2017

Shaikh Z

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3

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25 June 2017

Hsu CY

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4

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25 June 2017

1 March 2000

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Current Atherosclerosis Reports

25 June 2017

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25 June 2017

2

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25 June 2017

2

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25 June 2017

167-180

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https://scigraph.springernature.com/pub.10.1007/s11883-000-0112-2

25 June 2017

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cites work

Rodent models of cerebral ischemia

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Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury

21 January 2018

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Exacerbation of cerebral injury in mice that express the P-selectin gene: identification of P-selectin blockade as a new target for the treatment of stroke

21 January 2018

1 reference

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The neuroprotective effect of the novel AMPA receptor antagonist PD152247 (PNQX) in temporary focal ischemia in the rat.

21 January 2018

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Role of oxidants in ischemic brain damage

21 January 2018

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Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats.

21 January 2018

1 reference

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Immediate early gene expression in response to cerebral ischemia. Friend or foe?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Effects of lipopolysaccharide priming on acute ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Diffusion-weighted imaging studies of cerebral ischemia in gerbils. Potential relevance to energy failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Decompressive craniectomy, reperfusion, or a combination for early treatment of acute "malignant" cerebral hemispheric stroke in rats? Potential mechanisms studied by MRI.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Evaluation of early reperfusion and i.v. tPA therapy using diffusion- and perfusion-weighted MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

A randomized, double-blind, placebo-controlled pilot trial of intravenous magnesium sulfate in acute stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Functional, behavioral, and histological changes induced by transient global cerebral ischemia in rats: effects of cinnarizine and flunarizine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Clomethiazole acute stroke study (CLASS): results of a randomized, controlled trial of clomethiazole versus placebo in 1360 acute stroke patients.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Effect of U74006F on forebrain ischemia in rats

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group

21 January 2018

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Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Thromboxane, prostacyclin, and leukotrienes in cerebral ischemia.

21 January 2018

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Effects of CDP-choline on neurologic deficits and cerebral glucose metabolism in a rat model of cerebral ischemia.

21 January 2018

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A randomized efficacy trial of citicoline in patients with acute ischemic stroke.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Combination drug therapy and mild hypothermia: a promising treatment strategy for reversible, focal cerebral ischemia.

21 January 2018

1 reference

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Parallel antioxidant and antiexcitotoxic therapy improves outcome after incomplete global cerebral ischemia in dogs.

21 January 2018

1 reference

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Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist

21 January 2018

1 reference

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Combined treatment with MK-801 and nicardipine reduces global ischemic damage in the gerbil

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Recommendations for standards regarding preclinical neuroprotective and restorative drug development

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11883-000-0112-2

Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice

21 January 2018

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12 December 2020

Enhanced neuronal death from focal ischemia in AMPA-receptor transgenic mice.

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12 December 2020

Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat.

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12 December 2020

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

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12 December 2020

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

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12 December 2020

Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury.

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12 December 2020

Delayed intravenous administration of basic fibroblast growth factor (bFGF) reduces infarct volume in a model of focal cerebral ischemia/reperfusion in the rat.

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12 December 2020

Enlarged infarcts in endothelial nitric oxide synthase knockout mice are attenuated by nitro-L-arginine

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12 December 2020

The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat

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12 December 2020

Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats

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12 December 2020

Criteria for valid preclinical trials using animal stroke models

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12 December 2020

Attenuation of p53 expression protects against focal ischemic damage in transgenic mice

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12 December 2020

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

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12 December 2020

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

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12 December 2020

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

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12 December 2020

Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia

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12 December 2020

Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain

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12 December 2020

Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury

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12 December 2020

Over-additive protective effect of dizocilpine and NBQX against neuronal damage.

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12 December 2020

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

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12 December 2020

Experimental hypoxemic hypoxia: effects of variation in hematocrit on magnetic resonance T2*-weighted brain images.

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12 December 2020

Neocortical neural sprouting, synaptogenesis, and behavioral recovery after neocortical infarction in rats

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12 December 2020

Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons.

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12 December 2020

Quantitative regional brain water measurement with magnetic resonance imaging in a focal ischemia model.

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12 December 2020

Polyethylene glycol-conjugated superoxide dismutase in focal cerebral ischemia-reperfusion.

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12 December 2020

Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury

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12 December 2020

Expression of immediate early gene and growth factor mRNAs in a focal cerebral ischemia model in the rat

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12 December 2020

Apoptosis repressor genes Bcl-2 and Bcl-x-long are expressed in the rat brain following global ischemia.

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12 December 2020

Tissue plasminogen activator for acute ischemic stroke

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12 December 2020

The role of zinc in selective neuronal death after transient global cerebral ischemia

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12 December 2020

Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice

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12 December 2020

NF-kappaB is activated and promotes cell death in focal cerebral ischemia.

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12 December 2020

Caspases: enemies within

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12 December 2020

Effects of citicoline combined with thrombolytic therapy in a rat embolic stroke model

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12 December 2020

Zinc and brain injury

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12 December 2020

Pathobiology of ischaemic stroke: an integrated view

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12 December 2020

Diverse mechanisms of neuronal protection by nimodipine in experimental rabbit brain ischemia

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12 December 2020

Inhibition of proteolysis protects hippocampal neurons from ischemia

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12 December 2020

A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat.

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12 December 2020

Mitochondria and apoptosis

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12 December 2020

Neurotoxicity of NMDA receptor antagonists: an overview

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12 December 2020

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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12 December 2020

Mice expressing a bovine basic fibroblast growth factor transgene in the brain show increased resistance to hypoxemic-ischemic cerebral damage

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12 December 2020

Cerebroprotective effect of lamotrigine after focal ischemia in rats

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12 December 2020

The effect of mild hyperthermia and hypothermia on brain damage following 5, 10, and 15 minutes of forebrain ischemia

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12 December 2020

Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

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12 December 2020

Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

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12 December 2020

Attenuated c-fos mRNA induction after middle cerebral artery occlusion in CREB knockout mice does not modulate focal ischemic injury.

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12 December 2020

Combination therapy with U74006F (tirilazad mesylate), MK-801, insulin and diazepam in transient forebrain ischaemia.

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12 December 2020

Lack of evidence for neutrophil participation during infarct formation following focal cerebral ischemia in the rat

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12 December 2020

Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia

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12 December 2020

The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death

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12 December 2020

Functional benefit from clomethiazole treatment after focal cerebral ischemia in a nonhuman primate species.

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12 December 2020

Further evolution toward effective therapy for acute ischemic stroke

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12 December 2020

Experimental models for the investigation of brain ischemia.

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12 December 2020

Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage.

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12 December 2020

The glycine antagonist GV150526 protects somatosensory evoked potentials and reduces the infarct area in the MCAo model of focal ischemia in the rat.

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12 December 2020

Survival- and death-promoting events after transient cerebral ischemia: phosphorylation of Akt, release of cytochrome C and Activation of caspase-like proteases

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12 December 2020

Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury

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12 December 2020

Gene expression induced by cerebral ischemia: an apoptotic perspective

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12 December 2020

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

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12 December 2020

Effects of tissue plasminogen activator for acute ischemic stroke at one year. National Institute of Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator Stroke Study Group

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12 December 2020

Neuroprotective effects of lamotrigine enhanced by flunarizine in gerbil global ischemia.

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12 December 2020

The mitochondrial death/life regulator in apoptosis and necrosis

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12 December 2020

Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats.

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12 December 2020

Neuroprotective effects of combination therapy with tirilazad and magnesium in rats subjected to reversible focal cerebral ischemia

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12 December 2020

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

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12 December 2020

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12 December 2020

Bright and dark sides of nitric oxide in ischemic brain injury

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12 December 2020

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

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12 December 2020

Temporal profile of neuronal damage in a model of transient forebrain ischemia

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12 December 2020

Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis.

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12 December 2020

Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase

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12 December 2020

Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis?

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12 December 2020

Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat.

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12 December 2020

Experimental hypoxemic hypoxia: changes in R2* of brain parenchyma accurately reflect the combined effects of changes in arterial and cerebral venous oxygen saturation.

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12 December 2020

Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats

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12 December 2020

Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat.

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12 December 2020

Damage, repair, and mutagenesis in nuclear genes after mouse forebrain ischemia-reperfusion

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12 December 2020

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

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12 December 2020

Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene.

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12 December 2020

Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.

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12 December 2020

Tissue plasminogen activator reduces neurological damage after cerebral embolism.

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12 December 2020

Effects of combined postischemic hypothermia and delayed N-tert-butyl-alpha-pheylnitrone (PBN) administration on histopathologicaland behavioral deficits associated with transient global ischemia in rats

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12 December 2020

The changing landscape of ischaemic brain injury mechanisms.

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12 December 2020

Safety and tolerability of GV150526 (a glycine site antagonist at the N-methyl-D-aspartate receptor) in patients with acute stroke

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12 December 2020

Monotherapy with dextromethorphan or tirilazad--but not a combination of both--improves outcome after transient focal cerebral ischemia in rats

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12 December 2020

Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion.

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12 December 2020

Clinical utility of diffusion-weighted magnetic resonance imaging in the assessment of ischemic stroke

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12 December 2020

A caspase inhibitor blocks ischaemia-induced delayed neuronal death in the gerbil.

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12 December 2020

Neuroprotective role of ornithine decarboxylase activation in transient focal cerebral ischaemia: a study using ornithine decarboxylase-overexpressing transgenic rats

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12 December 2020

BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy

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12 December 2020

Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage

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12 December 2020

Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat.

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12 December 2020

Neuroprotection afforded by a combination of eliprodil and a thrombolytic agent, rt-PA, in a rat thromboembolic stroke model.

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12 December 2020

Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia.

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12 December 2020

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12 December 2020

Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemia

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12 December 2020

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

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12 December 2020

Reduction of cortical infarction and impairment of apoptosis in NGF-transgenic mice subjected to permanent focal ischemia.

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12 December 2020

Expression of c-fos and c-jun family genes after focal cerebral ischemia

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12 December 2020

Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia

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12 December 2020

Anti-ICAM-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat

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12 December 2020

Inflammatory mediators and stroke: new opportunities for novel therapeutics

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12 December 2020

Neutrophil inhibitory factor is neuroprotective after focal ischemia in rats

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12 December 2020

Caspases as treatment targets in stroke and neurodegenerative diseases

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12 December 2020

Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.

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12 December 2020

Viability thresholds and the penumbra of focal ischemia

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12 December 2020

Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage.

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12 December 2020

Ischemic cell death in brain neurons

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12 December 2020

Quantitative magnetic resonance imaging in experimental hypercapnia: improvement in the relation between changes in brain R2 and the oxygen saturation of venous blood after correction for changes in cerebral blood volume.

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12 December 2020

Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family.

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12 December 2020

Mice overexpressing extracellular superoxide dismutase have increased resistance to focal cerebral ischemia.

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12 December 2020

The neuroprotective actions of kynurenic acid and MK-801 in gerbils are synergistic and not related to hypothermia.

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12 December 2020

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis.

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12 December 2020

Diffusion-weighted MR imaging of acute stroke: correlation with T2-weighted and magnetic susceptibility-enhanced MR imaging in cats

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12 December 2020

Delayed treatment with aminoguanidine decreases focal cerebral ischemic damage and enhances neurologic recovery in rats

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12 December 2020

Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice.

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12 December 2020

Induction of interleukin-1 beta mRNA in rat brain after transient forebrain ischemia.

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12 December 2020

Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome

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12 December 2020

Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis.

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12 December 2020

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein.

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12 December 2020

Neuroprotective effects of gelsolin during murine stroke

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12 December 2020

Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2

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12 December 2020

Overexpression of thioredoxin in transgenic mice attenuates focal ischemic brain damage

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12 December 2020

10.1007/S11883-000-0112-2

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25 June 2017

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