Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2). (Q30583136)

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English	Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2). (English)

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

1

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Steve P. Watson

6

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

author name string

Uma Sinha

2

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Europe PubMed Central

PMC publication ID

17 November 2017

Anjali Pandey

3

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Johannes A Eble

4

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Christopher A O'Callaghan

5

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Europe PubMed Central

PMC publication ID

17 November 2017

language of work or name

0 references

publication date

21 December 2012

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Europe PubMed Central

PMC publication ID

17 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

288

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Europe PubMed Central

PMC publication ID

17 November 2017

7

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Europe PubMed Central

PMC publication ID

17 November 2017

5127-5135

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state

1 reference

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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.

1 reference

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Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling

1 reference

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PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model

1 reference

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Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets.

1 reference

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Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling

1 reference

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Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes

1 reference

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The platelet receptor CLEC-2 is active as a dimer

1 reference

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G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2

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Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development.

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Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.

1 reference

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The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade

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The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.

1 reference

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A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

1 reference

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Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

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Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec

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Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk.

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Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells

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1 reference

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Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase

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Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides

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Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases

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CLEC-2 activates Syk through dimerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

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Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

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1 reference

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1 reference

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Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion

1 reference

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Thermodynamic Study of the Binding of the Tandem-SH2 Domain of the Syk Kinase to a Dually Phosphorylated ITAM Peptide: Evidence for Two Conformers†

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.411462

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FcgammaRII tyrosine phosphorylation differs between FcgammaRII cross-linking and platelet-activating anti-platelet monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23264619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23264619

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.411462

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 November 2017

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