Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species (Q30574024)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Differential roles of the ubiquitin proteasome system and autophagy in the clearance of soluble and aggregated TDP-43 species (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

ubiquitin-proteasome system

5 March 2020

main subject

autophagy

0 references

0 references

author

Emma Scotter

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Caroline Vance

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Younbok Lee

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Boris Rogelj

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Christopher Shaw

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

author name string

Agnes L Nishimura

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Han-Jou Chen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Hazel Urwin

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Valentina Sardone

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Jacqueline C Mitchell

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

David C Rubinsztein

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

language of work or name

English

0 references

publication date

14 January 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

published in

Journal of Cell Science

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

volume

127

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

issue

Pt 6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

page(s)

1263-1278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

5 March 2020

copyright license

start time

18 May 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3953816/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport

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Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments

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The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

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Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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The Microprocessor complex mediates the genesis of microRNAs

28 July 2018

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Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

28 July 2018

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28 July 2018

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Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

28 July 2018

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Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

28 July 2018

1 reference

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Accelerated disease onset with stabilized familial amyotrophic lateral sclerosis (ALS)-linked mutant TDP-43 proteins

26 November 2018

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TDP-43 skeins show properties of amyloid in a subset of ALS cases

26 November 2018

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SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

26 November 2018

1 reference

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Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation

26 November 2018

1 reference

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Cyclosporin-A-induced prion protein aggresomes are dynamic quality-control cellular compartments

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.

26 November 2018

1 reference

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Autophagy: links with the proteasome

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

TDP-43 is recruited to stress granules in conditions of oxidative insult.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Involvement of macroautophagy in the dissolution of neuronal inclusions.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Attenuation of the p53 response to DNA damage by high cell density

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Autophagy regulates the processing of amino terminal huntingtin fragments

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Mutant dynactin in motor neuron disease.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Cytoplasmic dynein/dynactin mediates the assembly of aggresomes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

A new mathematical model for relative quantification in real-time RT-PCR

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3953816

Proteomic Analysis of Membrane-Associated Proteins from Rat Liver Autophagosomes

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24424030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1242/JCS.140087

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24424030%20AND%20SRC:MED&resulttype=core&format=json