Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice (Q30570222)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24550770%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice (English)

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8 March 2020

0 references

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ChEBI release 2020-05-28

2

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8 March 2020

author name string

Keishi Etori

series ordinal

1

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8 March 2020

Natsuko Tsujino

series ordinal

3

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8 March 2020

Takeshi Sakurai

series ordinal

4

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8 March 2020

publication date

31 January 2014

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Frontiers in Neuroscience

8 March 2020

published in

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8 March 2020

volume

8

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8 March 2020

page(s)

8

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Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice

8 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

20 June 2018

1 reference

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Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status

20 June 2018

1 reference

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ACS chemical neuroscience molecule spotlight on Suvorexant

20 June 2018

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Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone

20 June 2018

1 reference

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Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia

20 June 2018

1 reference

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Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists

20 June 2018

1 reference

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Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal

20 June 2018

1 reference

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Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice

20 June 2018

1 reference

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Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant

20 June 2018

1 reference

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Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia

20 June 2018

1 reference

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Almorexant, a dual orexin receptor antagonist for the treatment of insomnia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Promotion of sleep by targeting the orexin system in rats, dogs and humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Arousal effect of orexin A depends on activation of the histaminergic system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

To eat or to sleep? Orexin in the regulation of feeding and wakefulness

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Orexin directly excites orexin neurons through orexin 2 receptor

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Orexin receptor antagonism, a new sleep-promoting paradigm: an ascending single-dose study with almorexant

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Orexins activate histaminergic neurons via the orexin 2 receptor

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3907770

26 November 2018

Identifiers

DOI

10.3389/FNINS.2014.00008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24550770%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24550770%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24550770%20AND%20SRC:MED&resulttype=core&format=json