PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling. (Q30503120)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21670146%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling (English)

1 reference

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4 February 2020

main subject

Integrin-linked kinase

1 reference

GOA release 2020-03-11

author

Tillman Dahme

5

1 reference

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4 February 2020

12

Hugo A Katus

1 reference

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4 February 2020

1

Benjamin Meder

1 reference

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4 February 2020

author name string

Inken G Huttner

2

1 reference

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4 February 2020

Farbod Sedaghat-Hamedani

3

1 reference

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4 February 2020

Steffen Just

4

1 reference

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4 February 2020

Karen S Frese

6

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4 February 2020

Britta Vogel

7

1 reference

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4 February 2020

Doreen Köhler

8

1 reference

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4 February 2020

Wanda Kloos

9

1 reference

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4 February 2020

Jessica Rudloff

10

1 reference

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4 February 2020

Sabine Marquart

11

1 reference

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4 February 2020

Wolfgang Rottbauer

13

1 reference

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4 February 2020

language of work or name

English

0 references

publication date

13 June 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21670146%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

4 February 2020

published in

1 reference

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4 February 2020

volume

31

1 reference

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4 February 2020

issue

16

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4 February 2020

page(s)

3424-3435

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Integrin-linked kinase: a Scaffold protein unique among its ilk.

4 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

20 June 2018

1 reference

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Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy

20 June 2018

1 reference

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Integrin-linked kinase is an adaptor with essential functions during mouse development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Emerging gene knockout technology in zebrafish: zinc-finger nucleases

20 June 2018

1 reference

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Reverse genetics in zebrafish by TILLING.

20 June 2018

1 reference

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Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Consequences of loss of PINCH2 expression in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

The PINCH-ILK-parvin complexes: assembly, functions and regulation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

A new LIM protein containing an autoepitope homologous to "senescent cell antigen"

20 June 2018

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Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathies.

20 June 2018

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JunB-CBFbeta signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure.

26 November 2018

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A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo

26 November 2018

1 reference

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Nanospring behaviour of ankyrin repeats.

26 November 2018

1 reference

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VEGF-PLCgamma1 pathway controls cardiac contractility in the embryonic heart

26 November 2018

1 reference

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Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3147799

Effects of growth hormone on cardiac dysfunction and gene expression in genetic murine dilated cardiomyopathy.

26 November 2018

1 reference

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Distribution of vinculin in the Z-disk of striated muscle: analysis by laser scanning confocal microscopy

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21670146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A critical role of the PINCH-integrin-linked kinase interaction in the regulation of cell shape change and migration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21670146

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.05269-11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21670146%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21670146%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference