APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant (Q30501193)

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1 February 2020

title

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant (English)

1 reference

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1 February 2020

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1 reference

4

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1 February 2020

Luciano D'Adamio

5

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1 February 2020

Luciano D'Adamio

6

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1 February 2020

author name string

Robert Tamayev

1

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1 February 2020

Shuji Matsuda

2

1 reference

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1 February 2020

Luca Giliberto

3

1 reference

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1 February 2020

language of work or name

English

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publication date

17 May 2011

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1 February 2020

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1 February 2020

volume

30

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1 February 2020

issue

12

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1 February 2020

page(s)

2501-2509

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describes a project that uses

1 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3116289/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

1 reference

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Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis

14 July 2018

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Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease

14 July 2018

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Generation and initial characterization of FDD knock in mice

14 July 2018

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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.

14 July 2018

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An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.

14 July 2018

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Modeling familial British and Danish dementia

14 July 2018

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Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

14 July 2018

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Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

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Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

14 July 2018

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BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.

14 July 2018

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Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2.

14 July 2018

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When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease

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Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

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Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

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SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain

14 July 2018

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BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production

14 July 2018

1 reference

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The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production

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A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred

14 July 2018

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21 January 2018

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21 January 2018

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Exposing rats to a predator impairs spatial working memory in the radial arm water maze.

26 November 2018

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Genetics of Alzheimer's disease

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21587206

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2011.161

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21587206%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21587206%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference