Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations (Q30499194)

19 October 2017

Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations (English)

1 reference

19 October 2017

1

1 reference

19 October 2017

3

Satoshi Murakami

1 reference

19 October 2017

Hiroo Kenzaki

2

1 reference

PMCID

3065909

19 October 2017

Shoji Takada

series ordinal

4

1 reference

PMCID

3065909

19 October 2017

language of work or name

English

0 references

publication date

16 November 2010

1 reference

19 October 2017

Nature Communications

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19 October 2017

1

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19 October 2017

117

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Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

19 October 2017

start time

16 November 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Functional rotation of the transporter AcrB: insights into drug extrusion from simulations

1 reference

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Paddling mechanism for the substrate translocation by AAA+ motor revealed by multiscale molecular simulations

20 June 2018

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Insights from coarse-grained Gō models for protein folding and dynamics

20 June 2018

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Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa

20 June 2018

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The assembled structure of a complete tripartite bacterial multidrug efflux pump

20 June 2018

1 reference

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Drug transport mechanism of the AcrB efflux pump

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Covalently linked trimer of the AcrB multidrug efflux pump provides support for the functional rotating mechanism

20 June 2018

1 reference

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Dynamic energy landscape view of coupled binding and protein conformational change: induced-fit versus population-shift mechanisms

20 June 2018

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Multidrug efflux transporter, AcrB--the pumping mechanism

20 June 2018

1 reference

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Single molecule conformational dynamics of adenylate kinase: energy landscape, structural correlations, and transition state ensembles

20 June 2018

1 reference

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Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.

20 June 2018

1 reference

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Structural change and nucleotide dissociation of Myosin motor domain: dual go model simulation

20 June 2018

1 reference

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Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins

20 June 2018

1 reference

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Multiple molecular mechanisms for multidrug resistance transporters

20 June 2018

1 reference

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Drug export pathway of multidrug exporter AcrB revealed by DARPin inhibitors

20 June 2018

1 reference

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Comparison of multiple Amber force fields and development of improved protein backbone parameters

20 June 2018

1 reference

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Multiple-basin energy landscapes for large-amplitude conformational motions of proteins: Structure-based molecular dynamics simulations

20 June 2018

1 reference

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Conformational flexibility in the multidrug efflux system protein AcrA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Direct interaction of multidrug efflux transporter AcrB and outer membrane channel TolC detected via site-directed disulfide cross-linking

20 June 2018

1 reference

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Exploring protein native states and large-scale conformational changes with a modified generalized born model

20 June 2018

1 reference

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Efflux-mediated drug resistance in bacteria

20 June 2018

1 reference

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Crystal structure of bacterial multidrug efflux transporter AcrB

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes

20 June 2018

1 reference

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Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

The binding change mechanism for ATP synthase--some probabilities and possibilities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Molecular cloning and characterization of acrA and acrE genes of Escherichia coli

20 June 2018

1 reference

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Funnels, pathways, and the energy landscape of protein folding: a synthesis

20 June 2018

1 reference

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Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Theoretical Studies of Protein Folding

20 June 2018

1 reference

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Simple Allosteric Model for Membrane Pumps

20 June 2018

1 reference

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Spin glasses and the statistical mechanics of protein folding

20 June 2018

1 reference

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The Energy Landscapes and Motions of Proteins

20 June 2018

1 reference

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Protein folding funnels: a kinetic approach to the sequence-structure relationship

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Site-directed disulfide cross-linking shows that cleft flexibility in the periplasmic domain is needed for the multidrug efflux pump AcrB of Escherichia coli

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Slow Conformational Dynamics and Unfolding of the Calmodulin C-Terminal Domain

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Crystal structures of a multidrug transporter reveal a functionally rotating mechanism.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Slow Protein Conformational Dynamics from Multiple Experimental Structures: The Helix/Sheet Transition of Arc Repressor

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

AcrA, AcrB, and TolC of Escherichia coli Form a Stable Intermembrane Multidrug Efflux Complex

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Topological and energetic factors: what determines the structural details of the transition state ensemble and "en-route" intermediates for protein folding? An investigation for small globular proteins

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3065909

Approximate atomic surfaces from linear combinations of pairwise overlaps (LCPO)

26 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS1116

inferred from DOI database lookup

7 January 2021

based on heuristic

Molecular dynamics with coupling to an external bath

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNCOMMS1116

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS1116

1 reference

Dimensions Publication ID

19 October 2017

0 references

0 references

1 reference

19 October 2017

1 reference

PMCID

3065909