VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death (Q30487226)

18 August 2017

VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death (English)

1 reference

frontotemporal lobar degeneration

18 August 2017

1 reference

1 reference

Alison M Goate

6

0 references

Nigel J Cairns

7

object named as

Nigel J Cairns

1 reference

18 August 2017

Michael A Gitcho

1

1 reference

18 August 2017

Jeffrey Strider

2

1 reference

18 August 2017

Deborah Carter

3

1 reference

18 August 2017

Lisa Taylor-Reinwald

4

1 reference

18 August 2017

Mark S Forman

5

1 reference

18 August 2017

language of work or name

English

0 references

publication date

23 February 2009

1 reference

Journal of Biological Chemistry

18 August 2017

1 reference

18 August 2017

284

1 reference

18 August 2017

12384-12398

1 reference

18 August 2017

18

1 reference

Decreased ER-associated degradation of alpha-TCR induced by Grp78 depletion with the SubAB cytotoxin

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Late endocytic multivesicular bodies intersect the chlamydial inclusion in the absence of CD63.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC7901.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

TDP-43 A315T mutation in familial motor neuron disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

The differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

ER stress induces alternative nonproteasomal degradation of ER proteins but not of cytosolic ones

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Alteration of apoptotic signaling molecules as a function of time after radiation in human neuroblastoma cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

The 90-kDa heat shock protein stabilizes the polysomal ribonuclease 1 mRNA endonuclease to degradation by the 26S proteasome.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

West Nile Virus Infection Activates the Unfolded Protein Response, Leading to CHOP Induction and Apoptosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Phosphorylated PKR contributes the induction of GRP94 under ER stress

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Transient arrest in proteasomal degradation during inhibition of translation in the unfolded protein response

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Retinoic acid and nerve growth factor induce differential regulation of nicotinic acetylcholine receptor subunit expression in SN56 cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Structural insights into the p97-Ufd1-Npl4 complex.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Pathological consequences of VCP mutations on human striated muscle.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Mechanisms of disease: genetics of Paget's disease of bone and related disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Central pore residues mediate the p97/VCP activity required for ERAD

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

The valosin-containing protein (VCP) is a target of Akt signaling required for cell survival.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Inclusion body myopathy-associated mutations in p97/VCP impair endoplasmic reticulum-associated degradation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Valosin-containing protein phosphorylation at Ser784 in response to DNA damage

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Endoplasmic reticulum-associated degradation: exceptions to the rule

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Cdc2 kinase-dependent disassembly of endoplasmic reticulum (ER) exit sites inhibits ER-to-Golgi vesicular transport during mitosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Structural basis of the interaction between the AAA ATPase p97/VCP and its adaptor protein p47

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

DNA damage modulates nucleolar interaction of the Werner protein with the AAA ATPase p97/VCP

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Epidemiology and genetics of frontotemporal dementia/Pick's disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Clinical delineation and localization to chromosome 9p13.3-p12 of a unique dominant disorder in four families: hereditary inclusion body myopathy, Paget disease of bone, and frontotemporal dementia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin, and ATP.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2673306

Valosin-containing protein gene mutations: clinical and neuropathologic features.

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Autosomal dominant inclusion body myopathy, Paget disease of bone, and frontotemporal dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Novel VCP mutations in inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

The neuroprotection of insulin on ischemic brain injury in rat hippocampus through negative regulation of JNK signaling pathway by PI3K/Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

The maintenance of the endoplasmic reticulum network is regulated by p47, a cofactor of p97, through phosphorylation by cdc2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Autoantibodies from primary biliary cirrhosis patients with anti-p95c antibodies bind to recombinant p97/VCP and inhibit in vitro nuclear envelope assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Differential responses of human neuroblastoma and glioblastoma to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Proteasome inhibitor lactacystin disturbs the intracellular calcium homeostasis of dopamine neurons in ventral mesencephalic cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

NMDA antagonists exacerbate neuronal death caused by proteasome inhibition in cultured cortical and striatal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Induction of dopaminergic neurons from growth factor expanded neural stem/progenitor cell cultures derived from human first trimester forebrain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

The role of Drosophila Merlin in spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

A Golgi fragmentation pathway in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Carbonic anhydrase IX in oligodendroglial brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Structure of the N-terminal domain of PEX1 AAA-ATPase. Characterization of a putative adaptor-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M900992200

Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation

21 January 2018

1 reference

12 December 2020

Increased expression of valosin-containing protein (p97) is associated with lymph node metastasis and prognosis of pancreatic ductal adenocarcinoma

1 reference

12 December 2020

Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations

1 reference

12 December 2020

Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M900992200

1 reference

18 August 2017

1 reference

18 August 2017

1 reference