Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia (Q30467882)

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English	Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia	scientific article

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scholarly article

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Europe PubMed Central

11 August 2017

Mutations of the mouse ELMO domain containing 1 gene (Elmod1) link small GTPase signaling to actin cytoskeleton dynamics in hair cell stereocilia (English)

1 reference

Europe PubMed Central

11 August 2017

actin cytoskeleton

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author name string

Kenneth R Johnson

1

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Europe PubMed Central

11 August 2017

Chantal M Longo-Guess

2

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Europe PubMed Central

11 August 2017

Leona H Gagnon

3

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Europe PubMed Central

11 August 2017

language of work or name

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publication date

27 April 2012

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Europe PubMed Central

11 August 2017

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Europe PubMed Central

11 August 2017

7

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Europe PubMed Central

11 August 2017

4

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Europe PubMed Central

11 August 2017

e36074

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Europe PubMed Central

11 August 2017

copyright license

Creative Commons Attribution 4.0 International

27 April 2012

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April 2022 Public Data File from Crossref

copyright status

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Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Cell type-specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis

1 reference

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20 June 2018

Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells

1 reference

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20 June 2018

Roles of the espin actin-bundling proteins in the morphogenesis and stabilization of hair cell stereocilia revealed in CBA/CaJ congenic jerker mice

1 reference

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20 June 2018

A high-resolution anatomical atlas of the transcriptome in the mouse embryo

1 reference

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20 June 2018

Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome

1 reference

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20 June 2018

The small GTPase Rac1 regulates auditory hair cell morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Twinfilin 2 regulates actin filament lengths in cochlear stereocilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

The Elmo family forms an ancient group of actin-regulating proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Linking genes underlying deafness to hair-bundle development and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Dynamic length regulation of sensory stereocilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Dock4 regulates dendritic development in hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Regulation of actin cytoskeleton dynamics by Arf-family GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

The micromachinery of mechanotransduction in hair cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Hair bundles are specialized for ATP delivery via creatine kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Dock4 is regulated by RhoG and promotes Rac-dependent cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

The chloride intracellular channel protein CLIC5 is expressed at high levels in hair cell stereocilia and is essential for normal inner ear function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Supervised membrane swimming: small G-protein lifeguards regulate PIPK signalling and monitor intracellular PtdIns(4,5)P2 pools.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Characterization of a novel interaction between ELMO1 and ERM proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

The sensory and motor roles of auditory hair cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Hair-cell mechanotransduction and cochlear amplification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

When size matters: the dynamic regulation of stereocilia lengths

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Mutant analysis reveals whirlin as a dynamic organizer in the growing hair cell stereocilium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Radixin deficiency causes deafness associated with progressive degeneration of cochlear stereocilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Genetic insights into the morphogenesis of inner ear hair cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Radixin is a constituent of stereocilia in hair cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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Regulation of the Actin Cytoskeleton by PI(4,5)P2 and PI(3,4,5)P3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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A Receptor-Like Inositol Lipid Phosphatase Is Required for the Maturation of Developing Cochlear Hair Bundles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

20 June 2018

Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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Phosphoinositide regulation of the actin cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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Characterization of functional domains of mDia1, a link between the small GTPase Rho and the actin cytoskeleton.

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The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

1 reference

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CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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Mechanisms that regulate mechanosensory hair cell differentiation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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Role of myosin VI in the differentiation of cochlear hair cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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Rho GTPases and the actin cytoskeleton

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3338648

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Postnatal development of the hamster cochlea. II. Growth and differentiation of stereocilia bundles

1 reference

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A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

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The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells

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Development and properties of stereociliary link types in hair cells of the mouse cochlea

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Balanced levels of Espin are critical for stereociliary growth and length maintenance.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0036074

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1 reference

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https://pubmed.ncbi.nlm.nih.gov/22558334

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https://pubmed.ncbi.nlm.nih.gov/22558334

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inferred from PubMed ID database lookup

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based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0036074

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Europe PubMed Central

11 August 2017

2012PLoSO...736074J

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release_qy3cwyo6g5bitn5dlzjtbxnemq

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https://api.fatcat.wiki/v0/release/qy3cwyo6g5bitn5dlzjtbxnemq

24 November 2022

based on heuristic

mapped directly with Wikidata item

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Europe PubMed Central

11 August 2017

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Europe PubMed Central

11 August 2017

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