Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior (Q30462749)

10 August 2017

Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior (English)

1 reference

Jeremy Veenstra-VanderWeele

10 August 2017

0 references

0 references

Jeremy Veenstra-VanderWeele

0 references

Brent J Thompson

Brent J Thompson

10

0 references

Ana M. D. Carneiro

Ana M Carneiro

13

0 references

Ana M. Carneiro

Ana M Carneiro

13

0 references

James S. Sutcliffe

James S Sutcliffe

19

0 references

author name string

Christopher L Muller

2

1 reference

10 August 2017

Hideki Iwamoto

3

1 reference

10 August 2017

Jennifer E Sauer

4

1 reference

10 August 2017

W Anthony Owens

5

1 reference

10 August 2017

Charisma R Shah

6

1 reference

10 August 2017

Jordan Cohen

7

1 reference

10 August 2017

Padmanabhan Mannangatti

8

1 reference

10 August 2017

Tammy Jessen

9

1 reference

10 August 2017

Ran Ye

11

1 reference

10 August 2017

Travis M Kerr

12

1 reference

10 August 2017

Jacqueline N Crawley

14

1 reference

10 August 2017

Elaine Sanders-Bush

15

1 reference

10 August 2017

Douglas G McMahon

16

1 reference

10 August 2017

Sammanda Ramamoorthy

17

1 reference

10 August 2017

Lynette C Daws

18

1 reference

10 August 2017

Randy D Blakely

20

1 reference

10 August 2017

language of work or name

English

0 references

publication date

19 March 2012

1 reference

Proceedings of the National Academy of Sciences of the United States of America

10 August 2017

1 reference

10 August 2017

109

1 reference

10 August 2017

5469-5474

1 reference

10 August 2017

14

1 reference

Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits

10 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

A transient placental source of serotonin for the fetal forebrain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Serotonin mediates cross-modal reorganization of cortical circuits.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Behavioural phenotyping assays for mouse models of autism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Relationship between whole blood serotonin and repetitive behaviors in autism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Social approach in genetically engineered mouse lines relevant to autism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Enhanced activity of human serotonin transporter variants associated with autism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Calcium/calmodulin-dependent kinase II regulates the interaction between the serotonin transporter and syntaxin 1A.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Going with the flow: trafficking-dependent and -independent regulation of serotonin transport

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

A pharmacological analysis of mice with a targeted disruption of the serotonin transporter.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

3,4-Methylenedioxymethamphetamine- and 8-hydroxy-2-di-n-propylamino-tetralin-induced hypothermia: role and location of 5-hydroxytryptamine 1A receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Serotonin modulates the response of embryonic thalamocortical axons to netrin-1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Pten regulates neuronal arborization and social interaction in mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

The N-terminus of the norepinephrine transporter regulates the magnitude and selectivity of the transporter-associated leak current

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

A genetic approach to access serotonin neurons for in vivo and in vitro studies.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Autism and the serotonin transporter: the long and short of it

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Sex-specific genetic architecture of whole blood serotonin levels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Broad and narrow heritabilities of quantitative traits in a founder population

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Direct injection of 5-HT2A receptor agonists into the medial prefrontal cortex produces a head-twitch response in rats.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Functional expression of the plasma membrane serotonin transporter but not the vesicular monoamine transporter in human placental trophoblasts and choriocarcinoma cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Receptor stimulation causes slow inhibition of IRK1 inwardly rectifying K+ channels by direct protein kinase A-mediated phosphorylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children.

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Platelet serotonin levels in pervasive developmental disorders and mental retardation: diagnostic group differences, within-group distribution, and behavioral correlates

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Principal pathogenetic components and biological endophenotypes in autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Sensorimotor gating deficits in adults with autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

A quantitative trait locus analysis of social responsiveness in multiplex autism families

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

A principal components analysis of the Autism Diagnostic Interview-Revised.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1112345109

Evidence that genetic variation in 5-HT transporter expression is linked to changes in 5-HT2A receptor function

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3325657

26 November 2018

Identifiers

DOI

10.1073/PNAS.1112345109

1 reference

10 August 2017

0 references

1 reference

10 August 2017

1 reference