XG-102 administered to healthy male volunteers as a single intravenous infusion: a randomized, double-blind, placebo-controlled, dose-escalating study (Q30423728)

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English	XG-102 administered to healthy male volunteers as a single intravenous infusion: a randomized, double-blind, placebo-controlled, dose-escalating study	scientific article

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scholarly article

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Europe PubMed Central

11 November 2017

XG-102 administered to healthy male volunteers as a single intravenous infusion: a randomized, double-blind, placebo-controlled, dose-escalating study (English)

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Europe PubMed Central

11 November 2017

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based on heuristic

inferred from title

Luis López Lázaro

2

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11 June 2020

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11 June 2020

author name string

Catherine Deloche

1

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11 June 2020

Sébastien Mouz

3

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11 June 2020

Claire Abadie

5

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11 June 2020

Jean-Marc Combette

6

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11 June 2020

publication date

26 January 2014

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11 November 2017

Pharmacology Research & Perspectives

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11 June 2020

2

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11 June 2020

1

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11 June 2020

e00020

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11 June 2020

A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches

1 reference

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20 June 2018

The JNK inhibitor XG-102 protects against TNBS-induced colitis

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Role of the JNK pathway in human diseases

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Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies

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20 June 2018

Protection against ischemic cochlear damage by intratympanic administration of AM-111.

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20 June 2018

c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model

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20 June 2018

Lack of neuroprotection of inhibitory peptides targeting Jun/JNK after transient focal cerebral ischemia in spontaneously hypertensive rats

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20 June 2018

Type 2 diabetes is associated with altered NF-κB DNA binding activity, JNK phosphorylation, and AMPK phosphorylation in skeletal muscle after LPS.

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tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK.

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JNK3 as a therapeutic target for neurodegenerative diseases

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JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis

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JNK: a stress-activated protein kinase therapeutic strategies and involvement in Alzheimer's and various neurodegenerative abnormalities

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The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions

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20 June 2018

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

1 reference

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20 June 2018

Pathological roles of MAPK signaling pathways in human diseases

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Signal transduction pathways involved in drug-induced liver injury

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20 June 2018

c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges.

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20 June 2018

c-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186400

20 June 2018

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186400

20 June 2018

Cell-penetrating peptides in drug development: enabling intracellular targets

1 reference

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20 June 2018

A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186400

20 June 2018

A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186400

20 June 2018

Targeting JNK for therapeutic benefit: from junk to gold?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186400

20 June 2018

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186400

20 June 2018

Jun N-terminal kinase in rheumatoid arthritis.

1 reference

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20 June 2018

JNK inhibition and inflammation after cerebral ischemia

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21 January 2018

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

D-JNKi, a peptide inhibitor of c-Jun N-terminal kinase, promotes functional recovery after transient focal cerebral ischemia in rats.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

The c-Jun N-terminal kinase (JNK) inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischaemia in adult rats.

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https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

c-Jun N-terminal kinase pathway inhibition in intracerebral hemorrhage.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo

1 reference

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21 January 2018

Neuroprotection by NMDA preconditioning against glutamate cytotoxicity is mediated through activation of ERK 1/2, inactivation of JNK, and by prevention of glutamate-induced CREB inactivation.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

Inhibition of the JNK/AP-1 pathway reduces neuronal death and improves behavioral outcome after neonatal hypoxic-ischemic brain injury.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

Inhibition of c-Jun N-terminal kinase after hemorrhage but before resuscitation mitigates hepatic damage and inflammatory response in male rats

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

JNK activation is associated with intracellular beta-amyloid accumulation.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

c-Jun N-terminal kinase signaling pathway in excitotoxic cell death following kainic acid-induced status epilepticus

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase I/II study.

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https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

A peptide inhibitor of c-Jun N-terminal kinase for the treatment of endotoxin-induced uveitis

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

The JNK inhibitor D-JNKI-1 blocks apoptotic JNK signaling in brain mitochondria.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1002%2FPRP2.20

21 January 2018

Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186400

26 November 2018

Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition.

1 reference

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26 November 2018

Identifiers

10.1002/PRP2.20

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505576%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505576%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25505576%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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