Disordered epigenetic regulation in MLL-related leukemia (Q30422159)

21 June 2017

Disordered epigenetic regulation in MLL-related leukemia (English)

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21 June 2017

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Yue Zhang

1

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21 June 2017

Aili Chen

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2

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21 June 2017

Xiao-Mei Yan

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3

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21 June 2017

Gang Huang

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4

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21 June 2017

29 September 2012

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International Journal of Hematology

21 June 2017

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21 June 2017

96

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21 June 2017

4

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21 June 2017

428-437

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https://scigraph.springernature.com/pub.10.1007/s12185-012-1180-0

21 June 2017

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cites work

New insights to the MLL recombinome of acute leukemias

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Chromosomal translocations involving the MLL gene: molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

A COMPASS in the voyage of defining the role of trithorax/MLL-containing complexes: linking leukemogensis to covalent modifications of chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Definitive hematopoiesis requires the mixed-lineage leukemia gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Mixed lineage leukemia: a structure-function perspective of the MLL1 protein

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

PAFc, a key player in MLL-rearranged leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

The pathogenesis of mixed-lineage leukemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Controlling the elongation phase of transcription with P-TEFb

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

ALL-1 partial duplication in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

DNA hypermethylation and epigenetic silencing of the tumor suppressor gene, SLC5A8, in acute myeloid leukemia with the MLL partial tandem duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Emerging epigenetic targets and therapies in cancer medicine

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Chromatin modifications as therapeutic targets in MLL-rearranged leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Brd4 marks select genes on mitotic chromatin and directs postmitotic transcription

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Multisite protein modification and intramolecular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Therapeutic targeting of MLL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

Essential role of DOT1L in maintaining normal adult hematopoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1180-0

BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma

21 January 2018

1 reference

12 December 2020

A role for DOT1L inMLL-rearranged leukemias

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12 December 2020

Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice

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12 December 2020

Biological and therapeutic aspects of infant leukemia

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12 December 2020

Expression of HOXB genes is significantly different in acute myeloid leukemia with a partial tandem duplication of MLL vs. a MLL translocation: a cross-laboratory study

1 reference

12 December 2020

Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations

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12 December 2020

Defects in yolk sac hematopoiesis in Mll-null embryos.

1 reference

12 December 2020

All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders

1 reference

12 December 2020

Secondary leukemias induced by topoisomerase-targeted drugs

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12 December 2020

10.1007/S12185-012-1180-0

Identifiers

DOI

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Dimensions Publication ID

21 June 2017

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