Activation of Rac1-PI3K/Akt is required for epidermal growth factor-induced PAK1 activation and cell migration in MDA-MB-231 breast cancer cells (Q30420138)

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English	Activation of Rac1-PI3K/Akt is required for epidermal growth factor-induced PAK1 activation and cell migration in MDA-MB-231 breast cancer cells	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

15 August 2017

Activation of Rac1-PI3K/Akt is required for epidermal growth factor-induced PAK1 activation and cell migration in MDA-MB-231 breast cancer cells (English)

1 reference

Europe PubMed Central

15 August 2017

author name string

Yu Yang

1

1 reference

Europe PubMed Central

15 August 2017

Jun Du

2

1 reference

Europe PubMed Central

15 August 2017

Zhenzhen Hu

3

1 reference

Europe PubMed Central

15 August 2017

Jiaojing Liu

4

1 reference

Europe PubMed Central

15 August 2017

Yinhui Tian

5

1 reference

Europe PubMed Central

15 August 2017

Yichao Zhu

6

1 reference

Europe PubMed Central

15 August 2017

Le Wang

7

1 reference

Europe PubMed Central

15 August 2017

Luo Gu

8

1 reference

Europe PubMed Central

15 August 2017

publication date

1 July 2011

1 reference

Europe PubMed Central

15 August 2017

Journal of biomedical research

1 reference

Europe PubMed Central

15 August 2017

25

1 reference

Europe PubMed Central

15 August 2017

237-245

1 reference

Europe PubMed Central

15 August 2017

4

1 reference

Europe PubMed Central

15 August 2017

Lysophosphatidic acid induces MDA-MB-231 breast cancer cells migration through activation of PI3K/PAK1/ERK signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

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ErbB/EGF signaling and EMT in mammary development and breast cancer

1 reference

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ATP depletion-induced actin rearrangement reduces cell adhesion via p38 MAPK-HSP27 signaling in renal proximal tubule cells.

1 reference

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20 June 2018

EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2.

1 reference

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20 June 2018

Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress

1 reference

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20 June 2018

Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells

1 reference

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20 June 2018

Clinical implications of the ErbB/epidermal growth factor (EGF) receptor family and its ligands in ovarian cancer

1 reference

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20 June 2018

Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer

1 reference

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Acacetin-induced apoptosis of human breast cancer MCF-7 cells involves caspase cascade, mitochondria-mediated death signaling and SAPK/JNK1/2-c-Jun activation

1 reference

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VEGF signaling through NADPH oxidase-derived ROS.

1 reference

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20 June 2018

The signaling mechanism of ROS in tumor progression

1 reference

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20 June 2018

p21-activated kinases in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Epidermal growth factor receptor (EGFR) signaling in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Breast cancer metastasis: markers and models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Activated Akt expression in breast cancer: correlation with p53, Hdm2 and patient outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Reactive oxygen species in tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

ILK mediates actin filament rearrangements and cell migration and invasion through PI3K/Akt/Rac1 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

p21-activated kinase signaling in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Ratios of involved nodes in early breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Akt Phosphorylation of Serine 21 on Pak1 Modulates Nck Binding and Cell Migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

The GTPase Rac1 selectively regulates Salmonella invasion at the apical plasma membrane of polarized epithelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

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Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

The Akt proto-oncogene links Ras to Pak and cell survival signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Breast carcinoma: Pattern of metastasis at autopsy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

20 June 2018

Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

26 November 2018

Phosphoinositide 3-kinase regulates membrane Type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry.

1 reference

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26 November 2018

Adhesion of flowing monocytes to hypoxia-reoxygenation-exposed endothelial cells: role of Rac1, ROS, and VCAM-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

26 November 2018

E-cadherin homophilic ligation directly signals through Rac and phosphatidylinositol 3-kinase to regulate adhesive contacts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

26 November 2018

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

26 November 2018

Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3597073

26 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23554696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor promotes MDA-MB-231 breast cancer cell migration through a phosphatidylinositol 3'-kinase and phospholipase C-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23554696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1α expression through activation of AKT and P70S6K1 in human ovarian cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/23554696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23554696

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/S1674-8301(11)60032-8

1 reference

Europe PubMed Central

15 August 2017

release_wxhliqd4ybh4zkgms47abbv6yy

1 reference

https://api.fatcat.wiki/v0/release/wxhliqd4ybh4zkgms47abbv6yy

24 November 2022

based on heuristic

mapped directly with Wikidata item

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

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