Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor (Q30393936)

27 September 2017

Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor (English)

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27 September 2017

Justin A MacDonald

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Timothy A J Haystead

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object named as

Timothy A J Haystead

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27 September 2017

David A Carlson

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27 September 2017

Aaron S Franke

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27 September 2017

Douglas H Weitzel

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27 September 2017

Brittany L Speer

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27 September 2017

Philip F Hughes

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27 September 2017

Laura Hagerty

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27 September 2017

Christopher N Fortner

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27 September 2017

James M Veal

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27 September 2017

Thomas E Barta

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27 September 2017

Bartosz J Zieba

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27 September 2017

Avril V Somlyo

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27 September 2017

Cindy Sutherland

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27 September 2017

Jing Ti Deng

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27 September 2017

Michael P Walsh

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27 September 2017

language of work or name

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17 October 2013

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27 September 2017

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2715-2723

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describes a project that uses

27 September 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4445880/fullTextXML

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inferred from PubMed Central ID database lookup

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Kinase drug discovery--what's next in the field?

14 July 2018

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How chemoproteomics can enable drug discovery and development

14 July 2018

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7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes

14 July 2018

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Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.

14 July 2018

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The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling

14 July 2018

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Roles of Pim-3, a novel survival kinase, in tumorigenesis

14 July 2018

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Cancer-associated loss-of-function mutations implicate DAPK3 as a tumor-suppressing kinase

14 July 2018

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Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry

14 July 2018

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Phosphorylation-dependent control of ZIPK nuclear import is species specific

14 July 2018

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Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90

14 July 2018

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Par-4: a new activator of myosin phosphatase

14 July 2018

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Death-associated protein kinase-mediated cell death modulated by interaction with DANGER

14 July 2018

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Targeting protein kinases in central nervous system disorders

14 July 2018

1 reference

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DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression

14 July 2018

1 reference

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ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene

14 July 2018

1 reference

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Identification of a novel pyrazolo[3,4-d]pyrimidine able to inhibit cell proliferation of a human osteogenic sarcoma in vitro and in a xenograft model in mice

14 July 2018

1 reference

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The selectivity of protein kinase inhibitors: a further update

14 July 2018

1 reference

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The regulation of smooth muscle contractility by zipper-interacting protein kinase

14 July 2018

1 reference

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DAPk protein family and cancer

14 July 2018

1 reference

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The purinome, a complex mix of drug and toxicity targets

14 July 2018

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The death-associated protein kinases: structure, function, and beyond

14 July 2018

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ZIP kinase, a key regulator of myosin protein phosphatase 1.

14 July 2018

1 reference

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The role of sphingosine-1-phosphate in smooth muscle contraction

14 July 2018

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Synthesis of 1-(2-chloro-2-phenylethyl)-6-methylthio-1H-pyrazolo[3,4-d]pyrimidines 4-amino substituted and their biological evaluation.

14 July 2018

1 reference

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An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury

14 July 2018

1 reference

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The protein kinase complement of the human genome

14 July 2018

1 reference

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Structure, activity, regulation, and inhibitor discovery for a protein kinase associated with apoptosis and neuronal death

14 July 2018

1 reference

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Protein kinases--the major drug targets of the twenty-first century?

14 July 2018

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Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition

14 July 2018

1 reference

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A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.

14 July 2018

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Identification of the endogenous smooth muscle myosin phosphatase-associated kinase

14 July 2018

1 reference

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

14 July 2018

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Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively

14 July 2018

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Gamma-phosphate-linked ATP-sepharose for the affinity purification of protein kinases. Rapid purification to homogeneity of skeletal muscle mitogen-activated protein kinase kinase

14 July 2018

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Signal transduction and regulation in smooth muscle

14 July 2018

1 reference

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Arachidonic acid and diacylglycerol release associated with inhibition of myosin light chain dephosphorylation in rabbit smooth muscle.

14 July 2018

1 reference

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Receptor-coupled, permeabilized smooth muscle. Role of the phosphatidylinositol cascade, G-proteins, and modulation of the contractile response to Ca2+.

14 July 2018

1 reference

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Ca2+ channel blockers distinguish between G protein-coupled pharmacomechanical Ca2+ release and Ca2+ sensitization

14 July 2018

1 reference

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Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445880

Structure-activity relationship of novel DAPK inhibitors identified by structure-based virtual screening

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445880

Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia

26 November 2018

1 reference

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Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4445880

Role of pim-1 in smooth muscle cell proliferation

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24070067

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Opportunities to Target Specific Contractile Abnormalities with Smooth Muscle Protein Kinase Inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24070067

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CB400407C

1 reference

27 September 2017

1 reference

27 September 2017

PubMed publication ID

24070067

1 reference