Determinants of the activity and substrate recognition of breast cancer resistance protein (ABCG2). (Q30364846)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25036722%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Determinants of the activity and substrate recognition of breast cancer resistance protein (ABCG2) (English)

1 reference

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9 March 2020

3

1 reference

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9 March 2020

4

Leszek Fiedor

1 reference

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9 March 2020

2

Małgorzata Szczygieł

1 reference

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9 March 2020

author name string

Milena Julia Szafraniec

series ordinal

1

1 reference

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9 March 2020

language of work or name

English

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publication date

18 July 2014

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9 March 2020

published in

Drug Metabolism Reviews

1 reference

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9 March 2020

volume

46

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9 March 2020

issue

4

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9 March 2020

page(s)

459-474

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Nonprenylated rotenoids, a new class of potent breast cancer resistance protein inhibitors

9 March 2020

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ABCG2 modulates chlorothiazide permeability--in vitro-characterization of its interactions

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Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions

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Interaction of the breast cancer resistance protein with plant polyphenols

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Transplacental pharmacokinetics of glyburide, rhodamine 123, and BODIPY FL prazosin: effect of drug efflux transporters and lipid solubility.

21 January 2018

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21 January 2018

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Mutation of a single MalK subunit severely impairs maltose transport activity in Escherichia coli

21 January 2018

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Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

21 January 2018

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ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition

21 January 2018

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Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

21 January 2018

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Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib

21 January 2018

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Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

21 January 2018

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A multidrug resistance transporter from human MCF-7 breast cancer cells

21 January 2018

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Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate

21 January 2018

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The nature of amino acid 482 of human ABCG2 affects substrate transport and ATP hydrolysis but not substrate binding

21 January 2018

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Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds

21 January 2018

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Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens

21 January 2018

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Structure-activity relationships and quantitative structure-activity relationships for breast cancer resistance protein (ABCG2).

21 January 2018

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Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse.

21 January 2018

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HIV protease inhibitors are inhibitors but not substrates of the human breast cancer resistance protein (BCRP/ABCG2).

21 January 2018

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Modulation of breast cancer resistance protein (BCRP/ABCG2) by non-basic chalcone analogues.

21 January 2018

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Inhibition of carcinogenesis by isothiocyanates

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Identification of intra- and intermolecular disulfide bridges in the multidrug resistance transporter ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2.

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Multiple molecular mechanisms for multidrug resistance transporters

21 January 2018

1 reference

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Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport

21 January 2018

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Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro

21 January 2018

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ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

21 January 2018

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Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis

21 January 2018

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Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8

21 January 2018

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Breast cancer resistance protein exports sulfated estrogens but not free estrogens

21 January 2018

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Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.

21 January 2018

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Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance

21 January 2018

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Expression and functional characterization of human ABC transporter ABCG2 variants in insect cells

21 January 2018

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Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan

21 January 2018

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Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Membrane transport of dietary phenethyl isothiocyanate by ABCG2 (breast cancer resistance protein).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Metabolites of ginsenosides as novel BCRP inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Role of Cys-603 in dimer/oligomer formation of the breast cancer resistance protein BCRP/ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid in rat and human

21 January 2018

1 reference

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Breast cancer resistance protein directly confers SN-38 resistance of lung cancer cells.

21 January 2018

1 reference

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The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The ABC transporter Abcg2/Bcrp: role in hypoxia mediated survival

21 January 2018

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Walker A lysine mutations of TAP1 and TAP2 interfere with peptide translocation but not peptide binding.

21 January 2018

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Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients.

21 January 2018

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Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model

21 January 2018

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Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein

21 January 2018

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Effect of cysteine mutagenesis on the function and disulfide bond formation of human ABCG2.

21 January 2018

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Reduced cellular accumulation of topotecan: a novel mechanism of resistance in a human ovarian cancer cell line

21 January 2018

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ABC multidrug transporters: target for modulation of drug pharmacokinetics and drug-drug interactions

21 January 2018

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A global drug inhibition pattern for the human ATP-binding cassette transporter breast cancer resistance protein (ABCG2).

21 January 2018

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Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.

21 January 2018

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Purification and structural analyses of ABCG2.

21 January 2018

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Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2?

21 January 2018

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Breast cancer resistance protein (BCRP/ABCG2) transports fluoroquinolone antibiotics and affects their oral availability, pharmacokinetics, and milk secretion

21 January 2018

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A functional study on polymorphism of the ATP-binding cassette transporter ABCG2: critical role of arginine-482 in methotrexate transport.

21 January 2018

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Single amino acid substitutions in the transmembrane domains of breast cancer resistance protein (BCRP) alter cross resistance patterns in transfectants.

21 January 2018

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Single nucleotide polymorphisms result in impaired membrane localization and reduced atpase activity in multidrug transporter ABCG2.

21 January 2018

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Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions

21 January 2018

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Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein

21 January 2018

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Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer

21 January 2018

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Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).

21 January 2018

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Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity

21 January 2018

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Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells

21 January 2018

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Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation

21 January 2018

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High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter

21 January 2018

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Single amino acid (482) variants of the ABCG2 multidrug transporter: major differences in transport capacity and substrate recognition

21 January 2018

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Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2.

21 January 2018

1 reference

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Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.

21 January 2018

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Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).

21 January 2018

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Mutational analysis of ABCG2: role of the GXXXG motif

21 January 2018

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Purification of breast cancer resistance protein ABCG2 and role of arginine-482.

21 January 2018

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Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.

21 January 2018

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A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).

21 January 2018

1 reference

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Synergistic antitumor effect of combined use of adenoviral-mediated p53 gene transfer and antisense oligodeoxynucleotide targeting clusterin gene in an androgen-independent human prostate cancer model.

21 January 2018

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Pheophorbide a is a specific probe for ABCG2 function and inhibition.

21 January 2018

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21 January 2018

ABCG2: a perspective.

1 reference

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The human breast cancer resistance protein (BCRP/ABCG2) shows conformational changes with mitoxantrone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines.

21 January 2018

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The GxxxG motif: a framework for transmembrane helix-helix association

21 January 2018

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A new strategy of high-speed screening and quantitative structure-activity relationship analysis to evaluate human ATP-binding cassette transporter ABCG2-drug interactions

21 January 2018

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https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Reversal of breast cancer resistance protein (BCRP/ABCG2)‐mediated drug resistance by novobiocin, a coumermycin antibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Breast cancer resistance protein (BCRP/ABCG2).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Methoxy stilbenes as potent, specific, untransported, and noncytotoxic inhibitors of breast cancer resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

ABCG transporters: structure, substrate specificities and physiological roles : a brief overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Functional analysis of the human variants of breast cancer resistance protein: I206L, N590Y, and D620N.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Membrane topology of the human breast cancer resistance protein (BCRP/ABCG2) determined by epitope insertion and immunofluorescence

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Antipsychotic drugs inhibit the function of breast cancer resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Stereoselective interaction of pantoprazole with ABCG2. I. Drug accumulation in rat milk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Structure-activity relationships of multidrug resistance reversers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Interactions of cyclosporin a with breast cancer resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Oligomerization domain of the multidrug resistance-associated transporter ABCG2 and its dominant inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Breast cancer resistance protein (Bcrp/abcg2) is a major determinant of sulfasalazine absorption and elimination in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

BCRP transports dipyridamole and is inhibited by calcium channel blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

The breast cancer resistance protein (Bcrp1/Abcg2) limits fetal distribution of glyburide in the pregnant mouse: an Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037

Alteration of Substrate Specificity by Mutations at the His61Position in Predicted Transmembrane Domain 1 of Human MDR1/P-Glycoprotein†

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602532.2014.942037