Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. (Q30352594)

20 June 2017

title

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. (English)

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20 June 2017

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Pablo Bifani

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Mary Jackson

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Mary Jackson

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author name string

Kevin Pethe

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Jichan Jang

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Sunhee Kang

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Seijin Park

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Sujin Ahn

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Jan Jiricek

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Juyoung Jung

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Hee Kyoung Jeon

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Jonathan Cechetto

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Thierry Christophe

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Honggun Lee

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Marie Kempf

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Anne J Lenaerts

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Ha Pham

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Victoria Jones

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Min Jung Seo

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Young Mi Kim

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Mooyoung Seo

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Jeong Jea Seo

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Dongsik Park

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Yoonae Ko

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Inhee Choi

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Ryangyeo Kim

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Se Yeon Kim

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SeungBin Lim

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Seung-Ae Yim

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Jiyoun Nam

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Hwankyu Kang

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Haejin Kwon

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Chun-Taek Oh

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Yoojin Cho

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Yunhee Jang

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Junghwan Kim

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Adeline Chua

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Bee Huat Tan

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Mahesh B Nanjundappa

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Srinivasa P S Rao

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Whitney S Barnes

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René Wintjens

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John R Walker

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Sylvie Alonso

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Saeyeon Lee

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Jungjun Kim

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Soohyun Oh

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Taegwon Oh

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Ulf Nehrbass

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Sung-Jun Han

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Zaesung No

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Jinhwa Lee

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Priscille Brodin

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Sang-Nae Cho

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Kiyean Nam

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Jaeseung Kim

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language of work or name

English

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publication date

4 August 2013

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volume

19

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issue

9

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20 June 2017

page(s)

1157-1160

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Confronting multidrug-resistant tuberculosis

20 June 2017

cites work

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A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

21 January 2018

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

21 January 2018

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Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis

21 January 2018

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Early bactericidal activity and pharmacokinetics of PA-824 in smear-positive tuberculosis patients

21 January 2018

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Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance.

21 January 2018

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Delamanid for multidrug-resistant pulmonary tuberculosis

21 January 2018

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High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors

21 January 2018

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A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

21 January 2018

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Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening.

21 January 2018

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Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism

21 January 2018

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Regiospecific synthesis of 3-substituted imidazo[1,2-a]pyridines, imidazo[1,2-a]pyrimidines, and imidazo[1,2-c]pyrimidine

21 January 2018

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The challenge of new drug discovery for tuberculosis

21 January 2018

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Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis

21 January 2018

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Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs

21 January 2018

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Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB

21 January 2018

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Function of the cytochrome bc1-aa3 branch of the respiratory network in mycobacteria and network adaptation occurring in response to its disruption

21 January 2018

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Genes required for mycobacterial growth defined by high density mutagenesis

21 January 2018

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Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

21 January 2018

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A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis

21 January 2018

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X-ray structure of the dimeric cytochrome bc(1) complex from the soil bacterium Paracoccus denitrificans at 2.7-Å resolution

21 January 2018

1 reference

Inhibitor-complexed structures of the cytochrome bc1 from the photosynthetic bacterium Rhodobacter sphaeroides

21 January 2018

1 reference

Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment

21 January 2018

1 reference

Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex

21 January 2018

1 reference

Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

21 January 2018

1 reference

High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery

21 January 2018

1 reference

Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis

21 January 2018

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The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

21 January 2018

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Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis

21 January 2018

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Microtiter plate assays for inhibition of human, drug-metabolizing cytochromes P450

21 January 2018

1 reference

12 December 2020

National survey of drug-resistant tuberculosis in China

1 reference

12 December 2020

Multicenter study of MTT and resazurin assays for testing susceptibility to first-line anti-tuberculosis drugs.

1 reference

12 December 2020

Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)

1 reference

12 December 2020

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

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12 December 2020

Use of specific inhibitors on the mitochondrial bc1 complex

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12 December 2020

Identifiers

DOI

10.1038/NM.3262

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Dimensions Publication ID

20 June 2017

1052261221

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