Runx1/AML1 in normal and abnormal hematopoiesis. (Q30351255)

20 June 2017

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title

Runx1/AML1 in normal and abnormal hematopoiesis. (English)

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20 June 2017

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Tetsuya Yamagata

1

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20 June 2017

Kazuhiro Maki

series ordinal

2

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20 June 2017

Kinuko Mitani

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3

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20 June 2017

1 July 2005

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International Journal of Hematology

20 June 2017

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20 June 2017

82

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20 June 2017

1-8

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20 June 2017

1

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The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription

20 June 2017

1 reference

Crossref

https://api.crossref.org/works/10.1532%2FIJH97.05075

Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1532%2FIJH97.05075

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

21 January 2018

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12 December 2020

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

12 December 2020

Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia

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12 December 2020

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model

1 reference

12 December 2020

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.

1 reference

12 December 2020

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

1 reference

12 December 2020

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

1 reference

12 December 2020

Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice

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12 December 2020

The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression

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12 December 2020

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

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12 December 2020

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion

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12 December 2020

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

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12 December 2020

Leukemogenesis by the chromosomal translocations

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12 December 2020

EVI1 induces myelodysplastic syndrome in mice

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12 December 2020

The t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP.

1 reference

12 December 2020

Hematopoietic stem cell expansion and distinct myeloid developmental abnormalities in a murine model of the AML1-ETO translocation

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12 December 2020

Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML

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12 December 2020

Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia

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12 December 2020

Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage

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12 December 2020

The leukemia-associated transcription repressor AML1/MDS1/EVI1 requires CtBP to induce abnormal growth and differentiation of murine hematopoietic cells

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12 December 2020

The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies

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12 December 2020

CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3.

1 reference

12 December 2020

Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation

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12 December 2020

The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow

1 reference

12 December 2020

Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia

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12 December 2020

Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain.

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12 December 2020

In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis

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12 December 2020

The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

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12 December 2020

Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice.

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12 December 2020

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

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12 December 2020

Runx1 expression marks long-term repopulating hematopoietic stem cells in the midgestation mouse embryo

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12 December 2020

TEL-AML1, expressed from t(12;21) in human acute lymphocytic leukemia, induces acute leukemia in mice.

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12 December 2020

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

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12 December 2020

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function

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12 December 2020

CBFbeta allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium

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12 December 2020

Dysplastic definitive hematopoiesis in AML1/EVI1 knock-in embryos

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12 December 2020

Structure and expression pattern of a human MTG8/ETO family gene, MTGR1

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12 December 2020

Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins

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12 December 2020

TEL/AML1 shows dominant-negative effects over TEL as well as AML1.

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12 December 2020

The human promyelocytic leukemia zinc finger gene is regulated by the Evi-1 oncoprotein and a novel guanine-rich site binding protein

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12 December 2020

Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells

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12 December 2020

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

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12 December 2020

Recruitment of the nuclear receptor corepressor N-CoR by the TEL moiety of the childhood leukemia-associated TEL-AML1 oncoprotein

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12 December 2020

Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter

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12 December 2020

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

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12 December 2020

The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling

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12 December 2020

Overexpression of the AML1 proto-oncoprotein in NIH3T3 cells leads to neoplastic transformation depending on the DNA-binding and transactivational potencies.

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12 December 2020

E protein silencing by the leukemogenic AML1-ETO fusion protein

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12 December 2020

AML1-MTG8 leukemic protein induces the expression of granulocyte colony-stimulating factor (G-CSF) receptor through the up-regulation of CCAAT/enhancer binding protein epsilon.

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12 December 2020

A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

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12 December 2020

The fusion protein AML1-ETO in acute myeloid leukemia with translocation t(8;21) induces c-jun protein expression via the proximal AP-1 site of the c-jun promoter in an indirect, JNK-dependent manner.

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12 December 2020

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

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12 December 2020

High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients

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12 December 2020

High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia

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12 December 2020

Runx1/AML1 in leukemia: disrupted association with diverse protein partners

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12 December 2020

Role of RUNX family members in transcriptional repression and gene silencing

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12 December 2020

EVI1 abrogates interferon-alpha response by selectively blocking PML induction

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12 December 2020

Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias

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12 December 2020

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias

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12 December 2020

Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.

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12 December 2020

The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

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12 December 2020

Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family

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12 December 2020

Nomenclature for Runt-related (RUNX) proteins.

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12 December 2020

The expression of ETV6/CBFA2 (TEL/AML1) is not sufficient for the transformation of hematopoietic cell lines in vitro or the induction of hematologic disease in vivo

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12 December 2020

AML1-ETO decreases ETO-2 (MTG16) interactions with nuclear receptor corepressor, an effect that impairs granulocyte differentiation

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12 December 2020

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

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12 December 2020

Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development

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12 December 2020

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

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12 December 2020

Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression

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12 December 2020

The ETO (MTG8) gene family

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12 December 2020

The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1

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12 December 2020

ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors

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12 December 2020

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

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12 December 2020

ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

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12 December 2020

Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo

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12 December 2020

The transcription factor Evi-1.

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12 December 2020

The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2beta(CBFbeta) in the nucleus more efficiently than wild-type AML1

1 reference

12 December 2020

Identifiers

DOI

10.1532/IJH97.05075

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Dimensions Publication ID

20 June 2017

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