"Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. (Q30334349)

13 October 2017

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title

"Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits. (English)

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13 October 2017

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5

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13 October 2017

Grier P Page

1

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13 October 2017

Varghese George

series ordinal

2

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13 October 2017

Rodney C Go

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3

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13 October 2017

Patricia Z Page

series ordinal

4

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13 October 2017

language of work or name

English

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publication date

17 September 2003

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American Journal of Human Genetics

13 October 2017

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13 October 2017

73

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13 October 2017

4

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13 October 2017

711-719

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Viruses and Koch's Postulates

13 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1180596

The environment and disease: association or causation? 1965.

3 June 2018

1 reference

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Criteria for etiologic association of prevalent viruses with prevalent diseases; the virologist's dilemma

3 June 2018

1 reference

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Sequential tests for the detection of linkage

3 June 2018

1 reference

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Statistical significance for genomewide studies

3 June 2018

1 reference

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Mouse models as a tool for understanding neurodegenerative diseases

3 June 2018

1 reference

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Control of confounding of genetic associations in stratified populations

3 June 2018

1 reference

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Genetically altered mouse models: the good, the bad, and the ugly

3 June 2018

1 reference

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Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate

3 June 2018

1 reference

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Genetic associations: false or true?

3 June 2018

1 reference

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Population stratification and spurious allelic association

3 June 2018

1 reference

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Genetic associations in large versus small studies: an empirical assessment

3 June 2018

1 reference

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Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families

3 June 2018

1 reference

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Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

3 June 2018

1 reference

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The SNP Consortium website: past, present and future

3 June 2018

1 reference

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Finding genes that underlie complex traits

3 June 2018

1 reference

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3 June 2018

1 reference

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Point: population stratification: a problem for case-control studies of candidate-gene associations?

3 June 2018

1 reference

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Meta-analysis of genetic-linkage analysis of quantitative-trait loci

3 June 2018

1 reference

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A perspective on epistasis: limits of models displaying no main effect

3 June 2018

1 reference

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Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits

3 June 2018

1 reference

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Causation in epidemiology

3 June 2018

1 reference

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The genetic architecture of quantitative traits

3 June 2018

1 reference

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Controlling the false discovery rate in behavior genetics research

3 June 2018

1 reference

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Estimation of admixture and detection of linkage in admixed populations by a Bayesian approach: application to African-American populations

3 June 2018

1 reference

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Population admixture: detection by Hardy-Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits.

3 June 2018

1 reference

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Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene

3 June 2018

1 reference

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Identification and analysis of error types in high-throughput genotyping

3 June 2018

1 reference

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Gene mapping in the 20th and 21st centuries: statistical methods, data analysis, and experimental design.

3 June 2018

1 reference

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Meta-analysis by combining parameter estimates: simulated linkage studies

3 June 2018

1 reference

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Population choice in mapping genes for complex diseases

3 June 2018

1 reference

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Use of unlinked genetic markers to detect population stratification in association studies.

3 June 2018

1 reference

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From complex traits to complex alleles

3 June 2018

1 reference

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The emerging importance of genetics in epidemiologic research II. Issues in study design and gene mapping

3 June 2018

1 reference

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Estimating African American admixture proportions by use of population-specific alleles

3 June 2018

1 reference

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Linkage disequilibrium mapping in isolated populations: the example of Finland revisited

3 June 2018

1 reference

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Bayesian linkage analysis, or: how I learned to stop worrying and love the posterior probability of linkage

3 June 2018

1 reference

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Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase

3 June 2018

1 reference

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DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene.

3 June 2018

1 reference

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The future of genetic studies of complex human diseases

3 June 2018

1 reference

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Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates

3 June 2018

1 reference

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Genetic dissection of complex traits

3 June 2018

1 reference

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Mapping by admixture linkage disequilibrium in human populations: limits and guidelines

3 June 2018

1 reference

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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

3 June 2018

1 reference

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

3 June 2018

1 reference

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Linkage of early-onset familial breast cancer to chromosome 17q21

3 June 2018

1 reference

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Practical implications of modes of statistical inference for causal effects and the critical role of the assignment mechanism

3 June 2018

1 reference

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Causal propositions in clinical research and practice

3 June 2018

1 reference

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The Environment and Disease: Association or Causation?

3 June 2018

1 reference

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Diagnostic concordance of ICD-10 personality and comorbid disorders: a comparison of standard clinical assessment and structured interviews in a clinical setting.

20 June 2018

1 reference

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26 November 2018

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26 November 2018

1 reference

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The underlying principles of scientific publication.

26 November 2018

1 reference

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Once and Again—Issues Surrounding Replication in Genetic Association Studies

26 November 2018

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Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina

26 November 2018

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Computer programs for multilocus haplotyping of general pedigrees.

26 November 2018

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Statistical significance in psychological research

26 November 2018

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Genes, Environment, and Cardiovascular Disease

26 November 2018

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Errors and linkage disequilibrium interact multiplicatively when computing sample sizes for genetic case-control association studies

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Genetic dissection of complex traits

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Identifiers

DOI

10.1086/378900

1 reference

13 October 2017

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13 October 2017

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