SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase (Q30275524)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27806294%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

SEIPIN Regulates Lipid Droplet Expansion and Adipocyte Development by Modulating the Activity of Glycerol-3-phosphate Acyltransferase (English)

1 reference

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26 March 2020

1 reference

18

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26 March 2020

Yanfei Qi

3

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26 March 2020

Weiqin Chen

14

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26 March 2020

Xun Huang

19

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26 March 2020

Hongyuan Yang

21

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26 March 2020

author name string

Martin Pagac

1

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26 March 2020

Daniel E Cooper

2

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26 March 2020

Ivan E Lukmantara

4

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26 March 2020

Hoi Yin Mak

5

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26 March 2020

Zengying Wu

6

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26 March 2020

Yuan Tian

7

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26 March 2020

Zhonghua Liu

8

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26 March 2020

Mona Lei

9

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26 March 2020

Ximing Du

10

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26 March 2020

Charles Ferguson

11

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26 March 2020

Damian Kotevski

12

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26 March 2020

Pawel Sadowski

13

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26 March 2020

Salome Boroda

15

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26 March 2020

Thurl E Harris

16

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26 March 2020

George Liu

17

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26 March 2020

Rosalind A Coleman

20

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26 March 2020

publication date

1 November 2016

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26 March 2020

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26 March 2020

volume

17

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26 March 2020

page(s)

1546-1559

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26 March 2020

issue

6

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CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development.

26 March 2020

cites work

1 reference

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Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p(ΔNterm) only in combination with Ldb16p

3 June 2018

1 reference

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The seipin complex Fld1/Ldb16 stabilizes ER-lipid droplet contact sites

3 June 2018

1 reference

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Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast

3 June 2018

1 reference

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Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes

3 June 2018

1 reference

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Seipin oligomers can interact directly with AGPAT2 and lipin 1, physically scaffolding critical regulators of adipogenesis

3 June 2018

1 reference

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Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology.

3 June 2018

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Design, Synthesis, and Evaluation of 4- and 5-Substituted o-(Octanesulfonamido)benzoic Acids as Inhibitors of Glycerol-3-Phosphate Acyltransferase

3 June 2018

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Glycerol-3-phosphate acyltransferase-4-deficient mice are protected from diet-induced insulin resistance by the enhanced association of mTOR and rictor.

3 June 2018

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Seipin promotes adipose tissue fat storage through the ER Ca²⁺-ATPase SERCA.

3 June 2018

1 reference

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Lack of testicular seipin causes teratozoospermia syndrome in men.

3 June 2018

1 reference

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Control of lipid droplet size in budding yeast requires the collaboration between Fld1 and Ldb16.

3 June 2018

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The human lipodystrophy protein seipin is an ER membrane adaptor for the adipogenic PA phosphatase lipin 1.

3 June 2018

1 reference

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Analysis of naturally occurring mutations in the human lipodystrophy protein seipin reveals multiple potential pathogenic mechanisms

3 June 2018

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Thiazolidinediones partially reverse the metabolic disturbances observed in Bscl2/seipin-deficient mice

3 June 2018

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Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.

3 June 2018

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Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue

3 June 2018

1 reference

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Seipin: from human disease to molecular mechanism

3 June 2018

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A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

3 June 2018

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3 June 2018

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Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling

3 June 2018

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Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation

3 June 2018

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Controlling lipid fluxes at glycerol-3-phosphate acyltransferase step in yeast: unique contribution of Gat1p to oleic acid-induced lipid particle formation

3 June 2018

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Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis

3 June 2018

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Molecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis

3 June 2018

1 reference

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A role for phosphatidic acid in the formation of "supersized" lipid droplets

3 June 2018

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3 June 2018

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Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation

3 June 2018

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Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1

3 June 2018

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Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

3 June 2018

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Seipin, adipogenesis and lipid droplets.

3 June 2018

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3 June 2018

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3 June 2018

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Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors

3 June 2018

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3 June 2018

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The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation

3 June 2018

1 reference

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Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5647143

The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5647143

A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins

3 June 2018

1 reference

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Direct observation of individual endogenous protein complexes in situ by proximity ligation

3 June 2018

1 reference

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Genetic basis of lipodystrophies and management of metabolic complications

3 June 2018

1 reference

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Phospholipid metabolism regulated by a transcription factor sensing phosphatidic acid.

3 June 2018

1 reference

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Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria

3 June 2018

1 reference

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Getting started with yeast

3 June 2018

1 reference

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Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13.

3 June 2018

1 reference

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Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels

3 June 2018

1 reference

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Biosynthesis of phosphatidyl glycerophosphate in Escherichia coli

3 June 2018

1 reference

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Mice deleted for GPAT3 have reduced GPAT activity in white adipose tissue and altered energy and cholesterol homeostasis in diet-induced obesity.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5647143

Adipose-specific knockout of SEIPIN/BSCL2 results in progressive lipodystrophy.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5647143

Seipin ablation in mice results in severe generalized lipodystrophy.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5647143

Membrane topology of the human seipin protein

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5647143

Limited palmitoyl-CoA penetration into microsomal vesicles as evidenced by a highly latent ethanol acyltransferase activity

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27806294

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2016.10.037

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27806294%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27806294%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference