The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability (Q30274561)

9 January 2018

title

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability (English)

1 reference

9 January 2018

Solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

main subject

1 reference

GOA release 2020-03-11

author

John W. Elrod

16

1 reference

9 January 2018

Santhanam Shanmughapriya

Santhanam Shanmughapriya

6

0 references

Jeffery D. Molkentin

Jeffery D Molkentin

12

0 references

Jop H van Berlo

Jop H van Berlo

10

0 references

Steven R Houser

15

Steven R Houser

1 reference

9 January 2018

Jonathan P Lambert

Jonathan P Lambert

2

1 reference

ORCID Public Data File 2021

Xiongwen Chen

13

Xiongwen Chen

1 reference

9 January 2018

Muniswamy Madesh

14

Muniswamy Madesh

1 reference

9 January 2018

author name string

Timothy S Luongo

1

1 reference

9 January 2018

Polina Gross

3

1 reference

9 January 2018

Mary Nwokedi

4

1 reference

9 January 2018

Alyssa A Lombardi

5

1 reference

9 January 2018

April C Carpenter

7

1 reference

9 January 2018

Devin Kolmetzky

8

1 reference

9 January 2018

Emily J Tsai

11

1 reference

9 January 2018

language of work or name

English

0 references

publication date

26 April 2017

1 reference

9 January 2018

published in

Nature

1 reference

9 January 2018

volume

545

1 reference

9 January 2018

issue

7652

1 reference

9 January 2018

page(s)

93-97

1 reference

9 January 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5731245/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

The Mitochondrial Calcium Uniporter Selectively Matches Metabolic Output to Acute Contractile Stress in the Heart

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Standing of giants shoulders the story of the mitochondrial Na(+)Ca(2+) exchanger

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Mitochondrial calcium and the regulation of metabolism in the heart

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Calcium movement in cardiac mitochondria

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Unresolved questions from the analysis of mice lacking MCU expression

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

EMRE is an essential component of the mitochondrial calcium uniporter complex

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

The mitochondrial Na(+)/Ca(2+) exchanger

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

A conditional knockout resource for the genome-wide study of mouse gene function

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Calcium cycling and signaling in cardiac myocytes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Excitation-contraction coupling and mitochondrial energetics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Altered cardiac myocyte Ca regulation in heart failure.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

The use of lead citrate at high pH as an electron-opaque stain in electron microscopy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Evans Blue Dye as an in vivo marker of myofibre damage: optimising parameters for detecting initial myofibre membrane permeability.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5731245

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

26 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE22082

inferred from DOI database lookup

7 January 2021

based on heuristic

Myocyte recovery after mechanical circulatory support in humans with end-stage heart failure

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE22082

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE22082

1 reference

9 January 2018

Dimensions Publication ID

0 references

1 reference

9 January 2018

PubMed ID

28445457

1 reference

9 January 2018