Native state dynamics drive the unfolding of the SH3 domain of PI3 kinase at high denaturant concentration (Q30157052)

20 August 2017

Native state dynamics drive the unfolding of the SH3 domain of PI3 kinase at high denaturant concentration (English)

1 reference

20 August 2017

0 references

Ajazul Hamid Wani

1

1 reference

PMCID

2791584

20 August 2017

Jayant B Udgaonkar

series ordinal

2

1 reference

PMCID

2791584

20 August 2017

language of work or name

English

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publication date

17 November 2009

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Proceedings of the National Academy of Sciences of the United States of America

20 August 2017

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20 August 2017

106

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20 August 2017

49

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20 August 2017

20711-20716

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Urea impedes the hydrophobic collapse of partially unfolded proteins

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Revealing a concealed intermediate that forms after the rate-limiting step of refolding of the SH3 domain of PI3 kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Multiple routes and structural heterogeneity in protein folding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Dynamic personalities of proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Scope and utility of hydrogen exchange as a tool for mapping landscapes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

The interaction of guanidinium ions with a model peptide

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

An NMR perspective on enzyme dynamics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

The folding energy landscape of apoflavodoxin is rugged: hydrogen exchange reveals nonproductive misfolded intermediates

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Partial unfolding of diverse SH3 domains on a wide timescale

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Intrinsic dynamics of an enzyme underlies catalysis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Protein dynamics control proton transfer from bulk solvent to protein interior: a case study with a green fluorescent protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Molecular dynamics and protein function

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Multiple folding pathways of the SH3 domain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

EX1 hydrogen exchange and protein folding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Folding subdomains of thioredoxin characterized by native-state hydrogen exchange

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

The molecular basis for the chemical denaturation of proteins by urea

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Cytochrome c folding pathway: kinetic native-state hydrogen exchange

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Characterization of the unfolding of ribonuclease a by a pulsed hydrogen exchange study: evidence for competing pathways for unfolding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Hydrophobic core packing in the SH3 domain folding transition state

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Microsecond to minute dynamics revealed by EX1-type hydrogen exchange at nearly every backbone hydrogen bond in a native protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

The native state conformational ensemble of the SH3 domain from alpha-spectrin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Identification and localization of slow, natural, cooperative unfolding in the hematopoietic cell kinase SH3 domain by amide hydrogen exchange and mass spectrometry.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Different folding transition states may result in the same native structure

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Protein folding intermediates: native-state hydrogen exchange

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Protein denaturation. C. Theoretical models for the mechanism of denaturation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

Dynamics of folded proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2791584

How do small single-domain proteins fold?

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0908617106

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0908617106

Direct and high resolution characterization of cytochrome c equilibrium folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0908617106

Parallel protein-unfolding pathways revealed and mapped

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0908617106

Protein interactions with urea and guanidinium chloride. A calorimetric study

21 January 2018

1 reference

12 December 2020

Defining protein ensembles with native-state NH exchange: kinetics of interconversion and cooperative units from combined NMR and MS analysis

1 reference

12 December 2020

THE EFFECT OF COMPOUNDS OF THE UREA-GUANIDINIUM CLASS ON THE ACTIVITY COEFFICIENT OF ACETYLTETRAGLYCINE ETHYL ESTER AND RELATED COMPOUNDS

1 reference

12 December 2020

The native-state ensemble of proteins provides clues for folding, misfolding and function

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0908617106

1 reference

20 August 2017

0 references

1 reference

20 August 2017

1 reference

PMCID

2791584