Attacking pain at its source: new perspectives on opioids (Q30047792)

Europe PubMed Central

title

Attacking pain at its source: new perspectives on opioids (English)

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25 May 2017

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3

Halina Machelska

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25 May 2017

Christoph Stein

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author name string

Michael Schäfer

series ordinal

2

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25 May 2017

language of work or name

English

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publication date

August 2003

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25 May 2017

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25 May 2017

volume

9

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25 May 2017

issue

8

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25 May 2017

page(s)

1003-1008

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Exploring the opioid system by gene knockout

25 May 2017

cites work

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7 January 2021

New paths to pain relief

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7 January 2021

mu-Opposing actions of the kappa-opioid receptor

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7 January 2021

Peripheral analgesic and antiinflammatory effects of opioids

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7 January 2021

Multiple opiate receptor sites on primary afferent fibres

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7 January 2021

Opioid Receptors Undergo Axonal Flow

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7 January 2021

Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue

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7 January 2021

beta-Endorphin-containing memory-cells and mu-opioid receptors undergo transport to peripheral inflamed tissue

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7 January 2021

Mu opioid receptors and analgesia at the site of a peripheral nerve injury

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Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation

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Opioid receptors on peripheral sensory axons

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Immunohistochemical localization of delta opioid receptors in peripheral tissues

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No tolerance to peripheral morphine analgesia in presence of opioid expression in inflamed synovia

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The Meissner corpuscle revised: a multiafferented mechanoreceptor with nociceptor immunochemical properties.

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Chemical coding of neurons expressing delta- and kappa-opioid receptor and type I vanilloid receptor immunoreactivities in the porcine ileum

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Double in situ hybridization study on coexistence of mu-, delta- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia

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Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse

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Peripheral effects of morphine in neuropathic rats: role of sympathetic postganglionic nerve fibers

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7 January 2021

Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal

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7 January 2021

Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats

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7 January 2021

Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs

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Multiple neurological abnormalities in mice deficient in the G protein Go

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Selective opioid inhibition of small nociceptive neurons

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7 January 2021

Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP

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7 January 2021

Opioid inhibition of Ih via adenylyl cyclase

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7 January 2021

DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro

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Deficits in visceral pain and referred hyperalgesia in Nav1.8 (SNS/PN3)-null mice.

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A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain

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Peripheral mechanisms of opioid analgesia

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Lack of cross-tolerance between the antinociceptive effects of systemic morphine and asimadoline, a peripherally-selective kappa-opioid agonist, in CCI-neuropathic rats

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No pain, no gain: clinical excellence and scientific rigour--lessons learned from IA morphine

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Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site

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Involvement of activator protein-1 in transcriptional regulation of the human mu-opioid receptor gene

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7 January 2021

Expression of mu-, delta-, and kappa-opioid receptor-like immunoreactivities in rat dorsal root ganglia after carrageenan-induced inflammation

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Interleukin-1 beta induces long-term increase of axonally transported opiate receptors and substance P

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Perineurial defect and peripheral opioid analgesia in inflammation.

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Analgesic efficacy of peripheral opioids (all except intra-articular): a qualitative systematic review of randomised controlled trials

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Novel analgesic adjuncts for brachial plexus block: a systematic review

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Intraperitoneal versus interpleural morphine or bupivacaine for pain after laparoscopic cholecystectomy.

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Efficacy of peripheral morphine analgesia in inflamed, non-inflamed and perineural tissue of dental surgery patients

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Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal

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7 January 2021

Chronic treatment with systemic morphine induced tolerance to the systemic and peripheral antinociceptive effects of morphine on both carrageenin induced mechanical hyperalgesia and spinal c-Fos expression in awake rats

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7 January 2021

Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist--loperamide

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7 January 2021

Is methylnalorphinium the prototype of an ideal peripheral analgesic?

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7 January 2021

Peripheral morphine analgesia resistant to tolerance in chronic morphine-treated mice

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Opioid tolerance-in search of the holy grail

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Immune cell-derived beta-endorphin. Production, release, and control of inflammatory pain in rats

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Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain

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7 January 2021

Local analgesic effect of endogenous opioid peptides

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7 January 2021

Opioid peptide-expressing leukocytes: identification, recruitment, and simultaneously increasing inhibition of inflammatory pain.

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7 January 2021

Immunohistochemical localization of endomorphin-1 and endomorphin-2 in immune cells and spinal cord in a model of inflammatory pain.

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7 January 2021

T-Cell Function and Migration — Two Sides of the Same Coin

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7 January 2021

Co-expression of beta-endorphin with adhesion molecules in a model of inflammatory pain.

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7 January 2021

Opioid control of inflammatory pain regulated by intercellular adhesion molecule-1

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7 January 2021

Pain control in inflammation governed by selectins

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7 January 2021

Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue

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7 January 2021

Expression of corticotropin-releasing factor in inflamed tissue is required for intrinsic peripheral opioid analgesia

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7 January 2021

Modulation of peripheral endogenous opioid analgesia by central afferent blockade

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7 January 2021

Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis.

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7 January 2021

Endothelin-B receptor activation triggers an endogenous analgesic cascade at sites of peripheral injury

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7 January 2021

Therapeutic efficacy in experimental polyarthritis of viral-driven enkephalin overproduction in sensory neurons.

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7 January 2021

A pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753.

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7 January 2021

Role of blood-brain barrier P-glycoprotein in limiting brain accumulation and sedative side-effects of asimadoline, a peripherally acting analgaesic drug

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7 January 2021

Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats

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7 January 2021

Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis

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7 January 2021

Analgesic and antiinflammatory effects of two novel kappa-opioid peptides

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7 January 2021

Modulation of CGRP and PGE2 release from isolated rat skin by alpha-adrenoceptors and kappa-opioid-receptors

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7 January 2021

Substance P release from knee joint afferent terminals: modulation by opioids

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7 January 2021

Morphine inhibits the release of tumor necrosis factor in human peripheral blood mononuclear cell cultures

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7 January 2021

Effects of kappa opioids in the inflamed rat colon

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7 January 2021

Peripheral morphine administration blocks the development of hyperalgesia and allodynia after bone damage in the rat.

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7 January 2021

Intraarticular morphine versus dexamethasone in chronic arthritis

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7 January 2021

Local administration of morphine for analgesia after iliac bone graft harvest

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7 January 2021

Effects of morphine on corneal sensitivity and epithelial wound healing: implications for topical ophthalmic analgesia

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7 January 2021

Intravesical morphine analgesia after bladder surgery

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7 January 2021

Peripherally administered sufentanil inhibits pain perception after postpartum tubal ligation

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7 January 2021

Intra-articular morphine for pain relief after knee arthroscopy

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7 January 2021

Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man.

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7 January 2021

Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy

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7 January 2021

Gene-gun particle with pro-opiomelanocortin cDNA produces analgesia against formalin-induced pain in rats

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7 January 2021

Selective postoperative inhibition of gastrointestinal opioid receptors

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7 January 2021

Two faces for an opioid peptide--and more receptors for pain research

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7 January 2021

Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat.

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7 January 2021

Analgesic effect of intraarticular morphine after arthroscopic knee surgery

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7 January 2021

Dose-dependency of intra-articular morphine analgesia

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7 January 2021

Analgesic effects of peripherally administered opioids in clinical models of acute and chronic inflammation

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7 January 2021

Peripheral antinociceptive effects of morphine after burn injury

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7 January 2021

Potential uses of topical opioids in palliative care--report of 6 cases

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7 January 2021

Identifiers

DOI

10.1038/NM908

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25 May 2017

Consolidated OpenCitations Corpus – April 2017

1627250

1627250

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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