Corkscrew Dmel_CG3954 (Q29817978)

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Protein found in Drosophila melanogaster

CG3954-PD
enhancer of sevenless 1A
csw-PD
CG3954 gene product from transcript CG3954-RD
csw-PA
CG3954-PA
csw-PB
csw-PC
CG3954-PB
CG3954-PC
corkscrew
csw

Language	Label	Description	Also known as
English	Corkscrew Dmel_CG3954	Protein found in Drosophila melanogaster	CG3954-PD enhancer of sevenless 1A csw-PD CG3954 gene product from transcript CG3954-RD csw-PA CG3954-PA csw-PB csw-PC CG3954-PB CG3954-PC corkscrew csw

Statements

1 reference

25 May 2022

UniProt protein ID

Protein-tyrosine phosphatase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29349

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29349

Tyrosine specific protein phosphatases domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTP type protein phosphatase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

protein tyrosine phosphatase activity

determination method

5 references

24 April 2018

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

non-membrane spanning protein tyrosine phosphatase activity

determination method

2 references

protein binding

determination method

1 reference

8 April 2019

Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

phosphatase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

non-membrane spanning protein tyrosine phosphatase activity

determination method

4 references

8 April 2019

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

molecular adaptor activity

determination method

1 reference

1 January 2018

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

phosphotyrosine residue binding

determination method

1 reference

8 April 2019

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

transmembrane receptor protein tyrosine kinase adaptor activity

determination method

1 reference

8 April 2019

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

biological process

mitotic cell cycle

determination method

1 reference

8 April 2019

Multiple protein phosphatases are required for mitosis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

protein dephosphorylation

determination method

4 references

24 April 2018

Protein kinases and phosphatases in the Drosophila genome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

phagocytosis, engulfment

determination method

1 reference

8 April 2019

Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

epidermal growth factor receptor signaling pathway

determination method

3 references

8 April 2019

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Analysis of corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

terminal region determination

determination method

3 references

8 April 2019

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

ventral midline development

determination method

1 reference

8 April 2019

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

open tracheal system development

determination method

1 reference

8 April 2019

Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

epithelial cell migration, open tracheal system

determination method

1 reference

8 April 2019

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

primary branching, open tracheal system

determination method

1 reference

24 April 2018

Branching morphogenesis of the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

imaginal disc development

determination method

1 reference

8 April 2019

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

mesoderm development

determination method

1 reference

8 April 2019

Analysis of corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

dorsal/ventral axis specification, ovarian follicular epithelium

determination method

1 reference

8 April 2019

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

torso signaling pathway

determination method

5 references

24 April 2018

Genetic analysis of protein tyrosine phosphatases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

Localized activation of RTK/MAPK pathways during Drosophila development.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

Signal transduction pathway for anterior-posterior development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

24 April 2018

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

fibroblast growth factor receptor signaling pathway

determination method

1 reference

16 July 2018

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

anterior/posterior axis specification, embryo

determination method

1 reference

24 April 2018

Signal transduction pathway for anterior-posterior development in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

peptidyl-tyrosine dephosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

MASK, a large ankyrin repeat and KH domain-containing protein involved in Drosophila receptor tyrosine kinase signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

regulation of compound eye photoreceptor development

determination method

1 reference

8 April 2019

Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

sevenless signaling pathway

determination method

1 reference

24 April 2018

Cell fate specification in the Drosophila retina

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29349&geneProductId=UniProtKB:P29349

determination method

protein dephosphorylation

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

torso signaling pathway

determination method

5 references

8 April 2019

Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

photoreceptor cell development

determination method

1 reference

8 April 2019

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

fibroblast growth factor receptor signaling pathway

determination method

3 references

8 April 2019

The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

8 April 2019

Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29349

determination method

PTP type protein phosphatase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29349

Protein-tyrosine phosphatase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29349

Tyrosine specific protein phosphatases domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29349

Protein-tyrosine phosphatase, catalytic

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29349

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29349

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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