Xeroderma pigmentosum D Dmel_CG9433 (Q29811781)

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Protein found in Drosophila melanogaster

xeroderma pigmentosum D
lethal (2) SH2137
Xpd
CG9433-PA
CG9433 gene product from transcript CG9433-RA
xeroderma pigmentosum D ortholog
Xpd-PA

Language	Label	Description	Also known as
English	Xeroderma pigmentosum D Dmel_CG9433	Protein found in Drosophila melanogaster	xeroderma pigmentosum D lethal (2) SH2137 Xpd CG9433-PA CG9433 gene product from transcript CG9433-RA xeroderma pigmentosum D ortholog Xpd-PA

Statements

1 reference

25 May 2022

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7KVP9

RAD3/XPD family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7KVP9

ATP-dependent helicase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helical and beta-bridge domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DEAD2, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helicase-like, DEXD box c2 type, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

nucleic acid binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

DNA helicase activity

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

determination method

2 references

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

5'-3' DNA helicase activity

determination method

1 reference

16 July 2018

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

damaged DNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

RNA polymerase II CTD heptapeptide repeat kinase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

5'-3' DNA helicase activity

determination method

transcription factor TFIIH core complex

determination method

2 references

determination method

5 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

16 July 2018

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

16 July 2018

p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

16 July 2018

DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

transcription factor TFIIH holo complex

determination method

3 references

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

polytene chromosome

determination method

1 reference

8 April 2019

Physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

polytene chromosome puff

determination method

1 reference

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

polytene chromosome interband

determination method

1 reference

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

determination method

1 reference

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

biological process

promoter clearance from RNA polymerase II promoter

determination method

1 reference

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

transcription open complex formation at RNA polymerase II promoter

determination method

1 reference

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

nucleobase-containing compound metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

transcription initiation from RNA polymerase II promoter

determination method

1 reference

8 April 2019

Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

cellular response to DNA damage stimulus

determination method

1 reference

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

regulation of mitotic nuclear division

determination method

1 reference

8 April 2019

Xpd/Ercc2 regulates CAK activity and mitotic progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

regulation of syncytial blastoderm mitotic cell cycle

determination method

1 reference

8 April 2019

A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

determination method

3 references

16 July 2018

A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

16 July 2018

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

16 July 2018

Increased UV light sensitivity in transgenic Drosophila expressing the antisense XPD homolog

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

negative regulation of G2/M transition of mitotic cell cycle

determination method

1 reference

8 April 2019

Xpd/Ercc2 regulates CAK activity and mitotic progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

DNA duplex unwinding

determination method

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

regulation of chromosome segregation

determination method

1 reference

8 April 2019

Drosophila Xpd regulates Cdk7 localization, mitotic kinase activity, spindle dynamics, and chromosome segregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

regulation of nucleic acid-templated transcription

determination method

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7KVP9&geneProductId=UniProtKB:Q7KVP9

determination method

regulation of mitotic recombination

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

nucleotide-excision repair, DNA duplex unwinding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

response to oxidative stress

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

determination method

4 references

8 April 2019

A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

The Drosophila melanogaster homologue of the Xeroderma pigmentosum D gene product is located in euchromatic regions and has a dynamic response to UV light-induced lesions in polytene chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

Increased UV light sensitivity in transgenic Drosophila expressing the antisense XPD homolog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

nucleotide-excision repair, DNA incision

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

positive regulation of mitotic recombination

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7KVP9

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7KVP9

Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7KVP9

DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7KVP9

ATP-dependent helicase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7KVP9

Helical and beta-bridge domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7KVP9

Helicase-like, DEXD box c2 type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q7KVP9

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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