Topoisomerase 2 Dmel_CG10223 (Q29810279)

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Protein found in Drosophila melanogaster

Top2-PA
CG10223-PA
Top2-PB
topoisomerase II
DNA topoisomeriase II
CG10223-PB
CG10223 gene product from transcript CG10223-RB
Topoisomerase2
type II topoisomerase
type II DNA topoisomerase
DNA topoisomerase II
Top 2
solofuso
Top2
topoisomerase 2

Language	Label	Description	Also known as
English	Topoisomerase 2 Dmel_CG10223	Protein found in Drosophila melanogaster	Top2-PA CG10223-PA Top2-PB topoisomerase II DNA topoisomeriase II CG10223-PB CG10223 gene product from transcript CG10223-RB Topoisomerase2 type II topoisomerase type II DNA topoisomerase DNA topoisomerase II Top 2 solofuso Top2 topoisomerase 2

Statements

1 reference

25 May 2022

UniProt protein ID

Histidine kinase/HSP90-like ATPase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

DNA topoisomerase, type IIA-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

Ribosomal protein S5 domain 2-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

DNA topoisomerase, type IIA, subunit B, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

DNA topoisomerase II, eukaryotic-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

Ribosomal protein S5 domain 2-type fold, subgroup

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

C-terminal associated domain of TOPRIM, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA topoisomerase, type IIA, subunit B, domain 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA topoisomerase 2, TOPRIM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA topoisomerase, type IIA, subunit A/C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Histidine kinase/HSP90-like ATPase family

1 reference

based on heuristic

inferred from protein domain or family

TOPRIM domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA topoisomerase, type IIA, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

determination method

1 reference

1 January 2018

Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

determination method

3 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

chromatin binding

determination method

1 reference

1 January 2018

Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

satellite DNA binding

determination method

1 reference

1 January 2018

Displacement of D1, HP1 and topoisomerase II from satellite heterochromatin by a specific polyamide

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

determination method

1 reference

1 January 2018

During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

DNA topoisomerase activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

determination method

4 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

Single strand DNA cleavage reaction of duplex DNA by Drosophila topoisomerase II.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

protein binding

determination method

1 reference

1 January 2018

Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

isomerase activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

metal ion binding

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

condensed chromosome

determination method

1 reference

1 January 2018

Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

determination method

6 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

Single strand DNA cleavage reaction of duplex DNA by Drosophila topoisomerase II.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

Drosophila chromosome condensation proteins Topoisomerase II and Barren colocalize with Polycomb and maintain Fab-7 PRE silencing.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

Developmental regulation of DNA-topoisomerases during Drosophila embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

Essential functions of DNA topoisomerase I in Drosophila melanogaster.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

determination method

1 reference

1 January 2018

ACF, an ISWI-containing and ATP-utilizing chromatin assembly and remodeling factor.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

biological process

mitotic sister chromatid segregation

determination method

1 reference

1 January 2018

Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

resolution of meiotic recombination intermediates

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

sister chromatid segregation

determination method

3 references

1 January 2018

Condensin-dependent localisation of topoisomerase II to an axial chromosomal structure is required for sister chromatid resolution during mitosis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

DNA metabolic process

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

DNA topological change

determination method

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

Single strand DNA cleavage reaction of duplex DNA by Drosophila topoisomerase II.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

1 January 2018

Single-molecule analysis of DNA uncoiling by a type II topoisomerase.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

male meiosis chromosome segregation

determination method

1 reference

1 January 2018

Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

mitotic chromosome condensation

determination method

1 reference

1 January 2018

Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

mitotic G2 DNA damage checkpoint signaling

determination method

1 reference

1 January 2018

A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

chromosome condensation

determination method

1 reference

1 January 2018

The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

mitotic DNA integrity checkpoint signaling

determination method

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

metaphase plate congression

determination method

1 reference

1 January 2018

RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

determination method

1 reference

1 January 2018

During both interphase and mitosis, DNA topoisomerase II interacts with DNA as well as RNA through the protein's C-terminal domain.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15348&geneProductId=UniProtKB:P15348

determination method

DNA topoisomerase 2, TOPRIM domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

DNA topoisomerase, type IIA, subunit A/C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

DNA topoisomerase, type IIA, subunit B, domain 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

Histidine kinase/HSP90-like ATPase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

C-terminal associated domain of TOPRIM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

DNA topoisomerase, type IIA, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15348

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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