Death-associated inhibitor of apoptosis 1 Dmel_CG12284 (Q29809500)

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Protein found in Drosophila melanogaster

Language	Label	Description	Also known as
English	Death-associated inhibitor of apoptosis 1 Dmel_CG12284	Protein found in Drosophila melanogaster	inhibitor of apoptosis protein 1 drosophila inhibitor-of-apoptosis protein 1 DIAP1 degradation of inhibitors of apoptosis thread CG12284-PF Diap1-PA Diap1-PD CG12284-PC inhibitor of apoptotic protein 1 drosophila thread/inhibitor of apoptosis protein-1 Diap1-PE Death-associated inhibitor of apoptosis 1 drosophila inhibitor of apoptosis protein CG12284-PB lethal (3) 72CDe drosophila inhibitor of apoptosis protein 1 drosophila IAP1 Diap1-PF CG12284-PA drosophila inhibitor of apoptosis inhibitor of apoptosis-1 Diap1-PC CG12284 gene product from transcript CG12284-RF drosophila inhibitor of apoptosis Protein-1 drosophila inhibitor of apoptosis 1 Diap1-PB CG12284-PE CG12284-PD inhibitor of apoptosis inhibitors of apoptosis protein inhibitor of apoptosis 1

Statements

1 reference

25 May 2022

UniProt protein ID

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24306

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

BIR repeat domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

ubiquitin-protein transferase activity

determination method

1 reference

9 May 2019

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

cysteine-type endopeptidase inhibitor activity

determination method

1 reference

9 May 2019

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

protein binding

determination method

16 references

9 May 2019

Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

The Drosophila caspase DRONC is regulated by DIAP1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Metabolic regulation of Drosophila apoptosis through inhibitory phosphorylation of Dronc

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

zinc ion binding

determination method

1 reference

9 May 2019

Comprehensively surveying structure and function of RING domains from Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

ubiquitin conjugating enzyme binding

determination method

1 reference

9 May 2019

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

ubiquitin protein ligase binding

determination method

1 reference

9 May 2019

Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

determination method

1 reference

27 February 2018

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24306&geneProductId=UniProtKB:Q24306

determination method

ubiquitin-like protein conjugating enzyme binding

determination method

1 reference

9 May 2019

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

ubiquitin protein ligase activity

determination method

3 references

27 February 2018

Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24306&geneProductId=UniProtKB:Q24306

determination method

27 February 2018

Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24306&geneProductId=UniProtKB:Q24306

determination method

27 February 2018

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24306&geneProductId=UniProtKB:Q24306

determination method

NEDD8 ligase activity

determination method

1 reference

9 May 2019

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

caspase binding

determination method

1 reference

9 May 2019

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

ubiquitin-specific protease binding

determination method

1 reference

9 May 2019

The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

ubiquitin protein ligase activity

determination method

4 references

9 May 2019

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

determination method

1 reference

27 February 2018

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24306&geneProductId=UniProtKB:Q24306

determination method

determination method

1 reference

27 February 2018

The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24306&geneProductId=UniProtKB:Q24306

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

biological process

protein polyubiquitination

determination method

1 reference

9 May 2019

Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

apoptotic process

determination method

4 references

9 May 2019

Death to flies: Drosophila as a model system to study programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Apoptosis-an introduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

multicellular organism development

determination method

1 reference

9 May 2019

A comparison of programmed cell death between species

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

spermatogenesis

determination method

1 reference

9 May 2019

Anent the genomics of spermatogenesis in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

spermatid nucleus differentiation

determination method

1 reference

9 May 2019

Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

germ cell migration

determination method

1 reference

9 May 2019

Cell migration and programmed cell death of Drosophila germ cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

Wnt signaling pathway

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

positive regulation of protein ubiquitination

determination method

1 reference

8 April 2019

Inactivation of effector caspases through nondegradative polyubiquitylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

negative regulation of apoptotic process

determination method

8 references

9 May 2019

A comparison of programmed cell death between species

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Cell death in the fly comes of age.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

An emerging blueprint for apoptosis in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

6 references

8 April 2019

The fly caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

8 April 2019

Death to flies: Drosophila as a model system to study programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

8 April 2019

DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

8 April 2019

DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

8 April 2019

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

8 April 2019

Characterization of the Drosophila caspase, DAMM.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

sensory organ precursor cell division

determination method

1 reference

9 May 2019

Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

protein neddylation

determination method

1 reference

9 May 2019

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

negative regulation of compound eye retinal cell programmed cell death

determination method

1 reference

9 May 2019

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

antennal morphogenesis

determination method

1 reference

9 May 2019

Role of programmed cell death in patterning the Drosophila antennal arista.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

protein K48-linked ubiquitination

determination method

1 reference

9 May 2019

Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

positive regulation of canonical Wnt signaling pathway

determination method

1 reference

9 May 2019

XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

mitotic spindle assembly

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24306&geneProductId=UniProtKB:Q24306

determination method

inhibition of cysteine-type endopeptidase activity

determination method

1 reference

9 May 2019

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

inhibition of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

27 February 2018

The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q24306&geneProductId=UniProtKB:Q24306

determination method

negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

determination method

1 reference

9 May 2019

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

chaeta development

determination method

1 reference

9 May 2019

Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

9 May 2019

Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

positive regulation of border follicle cell migration

determination method

1 reference

9 May 2019

A sensitized PiggyBac-based screen for regulators of border cell migration in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

7 references

9 May 2019

The fly caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Death to flies: Drosophila as a model system to study programmed cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

DIAP2 functions as a mechanism-based regulator of drICE that contributes to the caspase activity threshold in living cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Characterization of the Drosophila caspase, DAMM.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q24306

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24306

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q24306

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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