Relish Dmel_CG11992 (Q29809204)

Immunoglobulin-like fold

1 reference

NF-kappa-B/Dorsal

1 reference

Immunoglobulin E-set

1 reference

Rel homology domain (RHD), DNA-binding domain superfamily

1 reference

Ankyrin repeat-containing domain superfamily

1 reference

IPT domain, protein family

1 reference

Rel homology dimerisation domain, protein family

1 reference

Rel homology domain (RHD), DNA-binding domain, protein family

1 reference

NFkappaB IPT domain, protein family

1 reference

Ankyrin repeat-containing domain, protein family

1 reference

Ankyrin repeat, protein family

1 reference

RNA polymerase II transcription regulatory region sequence-specific DNA binding

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

8 April 2019

The N-terminal half of the Drosophila Rel/NF-kappaB factor Relish, REL-68, constitutively activates transcription of specific Relish target genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

10 September 2018

Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

10 September 2018

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

8 April 2019

Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

chromatin binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

protein binding

3 references

8 April 2019

The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Heterodimers of NF-κB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

identical protein binding

1 reference

1 January 2018

Heterodimers of NF-κB transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

sequence-specific DNA binding

1 reference

8 April 2019

Functional conservation of Rel binding sites in drosophilid genomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

DNA-binding transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

1 reference

8 April 2019

cell component

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

8 April 2019

The Drosophila homolog of NTF-2, the nuclear transport factor-2, is essential for immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Discrete Functions of TRAF1 and TRAF2 in Drosophila melanogaster Mediated by c-Jun N-Terminal Kinase and NF-κB-Dependent Signaling Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Cactus-independent nuclear translocation of Drosophila RELISH.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

1 reference

8 April 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

8 April 2019

The Drosophila homolog of NTF-2, the nuclear transport factor-2, is essential for immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Discrete Functions of TRAF1 and TRAF2 in Drosophila melanogaster Mediated by c-Jun N-Terminal Kinase and NF-κB-Dependent Signaling Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

I-kappaB/NF-kappaB complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

7 November 2018

negative regulation of transcription by RNA polymerase II

biological process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

positive regulation of defense response to virus by host

1 reference

8 April 2019

A Novel System for the Launch of Alphavirus RNA Synthesis Reveals a Role for the Imd Pathway in Arthropod Antiviral Response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

1 reference

8 April 2019

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

1 reference

8 April 2019

transcription by RNA polymerase II

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

inflammatory response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

immune response

p38 MAPK signalling cascades: ancient roles and new functions

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

An essential complementary role of NF-kappaB pathway to microbicidal oxidants in Drosophila gut immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

positive regulation of antibacterial peptide biosynthetic process

IEP

Drosophila: the genetics of innate immune recognition and response

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Toll signaling: the enigma variations

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

NAS

1 January 2018

Regulated nuclear import of Rel proteins in the Drosophila immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Relish, a central factor in the control of humoral but not cellular immunity in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

IEP

4 references

8 April 2019

Iap2 is required for a sustained response in the Drosophila Imd pathway.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Cactus-independent nuclear translocation of Drosophila RELISH.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

positive regulation of antifungal peptide biosynthetic process

1 reference

8 April 2019

Relish, a central factor in the control of humoral but not cellular immunity in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

cellular response to DNA damage stimulus

1 reference

8 April 2019

Dynamic Coordination of Innate Immune Signaling and Insulin Signaling Regulates Systemic Responses to Localized DNA Damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

signal transduction

1 reference

1 January 2018

The immune response of Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

I-kappaB kinase/NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

Toll signaling pathway

1 reference

1 January 2018

The evolution and genetics of innate immunity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

positive regulation of gene expression

1 reference

8 April 2019

Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

response to cytokine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

cellular response to amino acid starvation

1 reference

8 April 2019

ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

NIK/NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 reference

16 July 2018

innate immune response

The complexity of genetic variation in a simple immune system

3 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

7 November 2018

7 November 2018

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

positive regulation of innate immune response

1 reference

8 April 2019

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

positive regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

positive regulation of transcription by RNA polymerase II

Drosophila: the genetics of innate immune recognition and response

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

dendrite morphogenesis

1 reference

8 April 2019

Functional Genomic Analyses of Two Morphologically Distinct Classes of Drosophila Sensory Neurons: Post-Mitotic Roles of Transcription Factors in Dendritic Patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

peripheral nervous system neuron development

1 reference

8 April 2019

NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

defense response to Gram-negative bacterium

The immune response of Drosophila melanogaster

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

1 January 2018

Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q94527&geneProductId=UniProtKB:Q94527

defense response to virus

IGI

1 reference

8 April 2019

The Imd pathway is involved in antiviral immune responses in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

peptidoglycan recognition protein signaling pathway

4 references

8 April 2019

The Drosophila caspase Dredd is required to resist gram-negative bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Cactus-independent nuclear translocation of Drosophila RELISH.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

negative regulation of stem cell proliferation

1 reference

8 April 2019

Mutations in the IMD Pathway and Mustard Counter Vibrio cholerae Suppression of Intestinal Stem Cell Division in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

positive regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

defense response to bacterium

1 reference

8 April 2019

Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

positive regulation of phagocytosis

1 reference

8 April 2019

Lysosomal Degradation Is Required for Sustained Phagocytosis of Bacteria by Macrophages.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

positive regulation of antibacterial peptide biosynthetic process

Regulated nuclear import of Rel proteins in the Drosophila immune response

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Relish, a central factor in the control of humoral but not cellular immunity in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

IEP

response to bacterium

1 reference

8 April 2019

Infection induces a survival program and local remodeling in the airway epithelium of the fly.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

1 reference

8 April 2019

positive regulation of transcription by RNA polymerase II

Akirin specifies NF-κB selectivity of Drosophila innate immune response via chromatin remodeling

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

defense response to Gram-negative bacterium

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

8 April 2019

Trade-offs between longevity and pathogen resistance in Drosophila melanogaster are mediated by NFkappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q94527

1 reference

Rel homology dimerisation domain

1 reference

ankyrin repeat

1 reference

NFkappaB IPT domain

1 reference

ankyrin repeat-containing domain

1 reference

Rel homology domain (RHD), DNA-binding domain

1 reference