Cell death abnormality protein 12;ELMO domain-containing protein CELE_Y106G6E.5 (Q29800140)

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Protein found in Caenorhabditis elegans

hypothetical protein
Cell death abnormality protein 12
ced-12
Cell death abnormality protein 12;hypothetical protein
Cell death abnormality protein 12;ELMO domain-containing protein

Language	Label	Description	Also known as
English	Cell death abnormality protein 12;ELMO domain-containing protein CELE_Y106G6E.5	Protein found in Caenorhabditis elegans	hypothetical protein Cell death abnormality protein 12 ced-12 Cell death abnormality protein 12;hypothetical protein Cell death abnormality protein 12;ELMO domain-containing protein

Statements

1 reference

25 May 2022

UniProt protein ID

0 references

Armadillo-like helical

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8STE5

Armadillo-type fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8STE5

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8STE5

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

ELMO domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Domain of unknown function DUF3361, protein family

1 reference

based on heuristic

inferred from protein domain or family

Caenorhabditis elegans

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

guanyl-nucleotide exchange factor activity

determination method

1 reference

1 January 2018

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

phosphatidylinositol-3,4,5-trisphosphate binding

determination method

1 reference

1 January 2018

The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

determination method

1 reference

1 January 2018

Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

proline-rich region binding

determination method

1 reference

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

phosphatidylinositol-4-phosphate binding

determination method

1 reference

1 January 2018

The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

phosphatidylinositol-3,5-bisphosphate binding

determination method

1 reference

1 January 2018

The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

protein-containing complex binding

determination method

1 reference

1 January 2018

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

determination method

3 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

plasma membrane

determination method

1 reference

1 January 2018

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

guanyl-nucleotide exchange factor complex

determination method

1 reference

1 January 2018

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

biological process

establishment of mitotic spindle orientation

determination method

1 reference

1 January 2018

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

phagocytosis, engulfment

determination method

1 reference

1 January 2018

A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

apoptotic process

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

actin filament organization

determination method

1 reference

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

determination method

6 references

1 January 2018

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

PH domain of ELMO functions in trans to regulate Rac activation via Dock180

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

regulation of cell migration

determination method

1 reference

1 January 2018

An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

actin cytoskeleton reorganization

determination method

3 references

1 January 2018

Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

engulfment of apoptotic cell

determination method

5 references

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

cytoskeletal rearrangement involved in phagocytosis, engulfment

determination method

3 references

1 January 2018

Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 January 2018

C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

left/right axis specification

determination method

1 reference

1 January 2018

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

positive regulation of engulfment of apoptotic cell

determination method

1 reference

1 January 2018

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

apoptotic process involved in development

determination method

positive regulation of distal tip cell migration

determination method

1 reference

1 January 2018

The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8STE5

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8STE5

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8STE5

Domain of unknown function DUF3361

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8STE5

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Microsoft Academic ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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