Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats (Q29347083)

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English	Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats	scientific article

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scholarly article

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Europe PubMed Central

11 April 2017

Losartan improves aortic endothelium-dependent relaxation via proline-rich tyrosine kinase 2/Src/Akt pathway in type 2 diabetic Goto-Kakizaki rats (English)

1 reference

Europe PubMed Central

11 April 2017

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author name string

Shingo Nemoto

1

1 reference

Europe PubMed Central

11 April 2017

Tsuneo Kobayashi

2

1 reference

Europe PubMed Central

11 April 2017

Kumiko Taguchi

3

1 reference

Europe PubMed Central

11 April 2017

Takayuki Matsumoto

4

1 reference

Europe PubMed Central

11 April 2017

Katsuo Kamata

5

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Europe PubMed Central

11 April 2017

publication date

16 September 2011

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Europe PubMed Central

11 April 2017

American Journal of Physiology Heart and Circulatory Physiology

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Europe PubMed Central

11 April 2017

301

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Europe PubMed Central

11 April 2017

H2383-94

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Europe PubMed Central

11 April 2017

6

1 reference

Europe PubMed Central

11 April 2017

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

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Losartan, an angiotensin type 1 receptor antagonist, improves endothelial function in non-insulin-dependent diabetes.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

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Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Altered regulation of renin secretion by insulinlike growth factors and angiotensin II in diabetic rats

1 reference

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Plasma adiponectin and insulin sensitivity in overweight and normal-weight middle-aged premenopausal women

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

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Ca2+ mobilization in the aortic endothelium in streptozotocin-induced diabetic and cholesterol-fed mice

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

ANG II enhances contractile responses via PI3-kinase p110 delta pathway in aortas from diabetic rats with systemic hyperinsulinemia

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Short-term insulin treatment and aortic expressions of IGF-1 receptor and VEGF mRNA in diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

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Differential expression of alpha2D-adrenoceptor and eNOS in aortas from early and later stages of diabetes in Goto-Kakizaki rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Diabetic state, high plasma insulin and angiotensin II combine to augment endothelin-1-induced vasoconstriction via ETA receptors and ERK

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Calcium dynamics and vasomotion in arteries subject to isometric, isobaric, and isotonic conditions

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat thoracic aorta.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Hyperglycemia contributes to impaired insulin response in GK rat islets

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Mechanisms underlying the losartan treatment-induced improvement in the endothelial dysfunction seen in mesenteric arteries from type 2 diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Losartan normalizes endothelium-derived hyperpolarizing factor-mediated relaxation by activating Ca2+-activated K+ channels in mesenteric artery from type 2 diabetic GK rat.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Mechanism of endothelial nitric oxide synthase phosphorylation and activation by thrombin.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Impaired insulin secretion and excessive hepatic glucose production are both early events in the diabetic GK rat.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Increased angiotensin-converting enzyme activities in diabetes mellitus: analysis of diabetes type, state of metabolic control and occurrence of diabetic vascular disease

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Adaptation and maladaptation of the heart in diabetes: Part I: general concepts

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Dietary salt activates an endothelial proline-rich tyrosine kinase 2/c-Src/phosphatidylinositol 3-kinase complex to promote endothelial nitric oxide synthase phosphorylation

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00178.2011

21 January 2018

Identifiers

10.1152/AJPHEART.00178.2011

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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