Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling (Q29346873)

11 April 2017

Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling (English)

1 reference

SsDNA endodeoxyribonuclease SAE2 YGL175C

11 April 2017

0 references

1 reference

GOA release 2020-03-11

author

Naofumi Handa

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Huan Chen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Roberto A Donnianni

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Sarah K Deng

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Julyun Oh

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Leonid A Timashev

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Stephen C Kowalczykowski

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Lorraine S Symington

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

23 March 2015

1 reference

Proceedings of the National Academy of Sciences of the United States of America

11 April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

15

1 reference

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7 June 2020

page(s)

E1880-7

1 reference

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describes a project that uses

7 June 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4403154/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks

1 reference

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DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

11 April 2017

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Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling

11 April 2017

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Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1

11 April 2017

1 reference

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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

11 April 2017

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Temporally and biochemically distinct activities of Exo1 during meiosis: double-strand break resection and resolution of double Holliday junctions

11 April 2017

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DNA end resection: many nucleases make light work

11 April 2017

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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

11 April 2017

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Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

11 April 2017

1 reference

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Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

11 April 2017

1 reference

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Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

11 April 2017

1 reference

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Fidelity of mitotic double-strand-break repair in Saccharomyces cerevisiae: a role for SAE2/COM1

11 April 2017

1 reference

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A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2.

11 April 2017

1 reference

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Double-strand break end resection and repair pathway choice

11 April 2017

1 reference

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Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins

11 April 2017

1 reference

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Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage

11 April 2017

1 reference

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Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways

11 April 2017

1 reference

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Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination

11 April 2017

1 reference

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Functional interplay between the 53BP1-ortholog Rad9 and the Mre11 complex regulates resection, end-tethering and repair of a double-strand break.

11 April 2017

1 reference

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RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

3 June 2018

1 reference

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Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae

3 June 2018

1 reference

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Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks

3 June 2018

1 reference

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Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks.

3 June 2018

1 reference

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Functional interplay of the Mre11 nuclease and Ku in the response to replication-associated DNA damage

3 June 2018

1 reference

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The MRE11 complex: starting from the ends.

3 June 2018

1 reference

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Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks

3 June 2018

1 reference

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Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

3 June 2018

1 reference

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DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2.

3 June 2018

1 reference

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Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae.

3 June 2018

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Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

3 June 2018

1 reference

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Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway

3 June 2018

1 reference

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DNA helicases Sgs1 and BLM promote DNA double-strand break resection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Saccharomyces cerevisiae Sae2- and Tel1-dependent single-strand DNA formation at DNA break promotes microhomology-mediated end joining

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Surviving the breakup: the DNA damage checkpoint.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Requirement of the MRN complex for ATM activation by DNA damage

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4403154

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1503331112

Sgs1 and Sae2 promote telomere replication by limiting accumulation of ssDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1503331112

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1503331112

Spk1/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1503331112

The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25831494

12 December 2020

inferred from PubMed ID database lookup

A DNA damage response pathway controlled by Tel1 and the Mre11 complex

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25831494

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.1503331112

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

0 references

release_imetiq6objgcxavxdfdomtxaaq

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/imetiq6objgcxavxdfdomtxaaq

24 November 2022

mapped directly with Wikidata item

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25831494%20AND%20SRC:MED&resulttype=core&format=json