Structural basis for the unique biological function of small GTPase RHEB (Q28910458)

GOA release 2020-03-11

GDP binding

1 reference

GOA release 2020-03-11

author

Eddy Arnold

6

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author name string

Yadong Yu

1

1 reference

7 March 2017

Sheng Li

2

1 reference

7 March 2017

Xiang Xu

3

1 reference

7 March 2017

Yong Li

4

1 reference

7 March 2017

Kunliang Guan

5

1 reference

7 March 2017

Jianping Ding

Journal of Biological Chemistry

7

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7 March 2017

language of work or name

English

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publication date

29 April 2005

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7 March 2017

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7 March 2017

280

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7 March 2017

17093–17100

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7 March 2017

17

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7 March 2017

Isolation of cDNA and genomic clones of a human Ras-related GTP-binding protein gene and its chromosomal localization to the long arm of chromosome 7, 7q36

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The Rheb family of GTP-binding proteins

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

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Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501253200

Rheb fills a GAP between TSC and TOR.

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1 reference

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Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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Tuberous sclerosis complex: from Drosophila to human disease.

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Drosophila Rheb GTPase is required for cell cycle progression and cell growth

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1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501253200

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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https://api.crossref.org/works/10.1074%2FJBC.M501253200

TSC2: filling the GAP in the mTOR signaling pathway

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Two loci for tuberous sclerosis: one on 9q34 and one on 16p13.

21 January 2018

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Tuberous sclerosis complex

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Comparative analysis and genomic structure of the tuberous sclerosis 2 (TSC2) gene in human and pufferfish

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Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

21 January 2018

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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The guanine nucleotide-binding switch in three dimensions

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The GTPase-activating protein Rap1GAP uses a catalytic asparagine

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Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

21 January 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

21 January 2018

1 reference

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

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Ras/Rap effector specificity determined by charge reversal

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The Ras branch of small GTPases: Ras family members don't fall far from the tree

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The arginine finger strikes again

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