Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration (Q28834138)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27008180%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

title

Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration (English)

1 reference

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30 March 2020

1 reference

1 reference

2

1 reference

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30 March 2020

Cedric Bardy

6

1 reference

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30 March 2020

Ronald M. Evans

8

1 reference

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30 March 2020

Tony Hunter

10

1 reference

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30 March 2020

9

Fred H Gage

1 reference

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30 March 2020

author name string

Xinde Zheng

1

1 reference

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30 March 2020

Mingji Jin

3

1 reference

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30 March 2020

Yongsung Kim

4

1 reference

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30 March 2020

Weiwei Fan

5

1 reference

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30 March 2020

Travis Berggren

7

1 reference

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30 March 2020

language of work or name

English

0 references

publication date

23 March 2016

1 reference

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30 March 2020

1 reference

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30 March 2020

volume

5

1 reference

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30 March 2020

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

16 March 2017

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Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

7 April 2017

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Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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3 June 2018

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The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis

3 June 2018

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

3 June 2018

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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

3 June 2018

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AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization

3 June 2018

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Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

3 June 2018

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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

3 June 2018

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Molecular mechanisms and potential therapeutical targets in Huntington's disease

3 June 2018

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Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease

3 June 2018

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Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4846388

Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy

3 June 2018

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Leigh and Leigh-like syndrome in children and adults

3 June 2018

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Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity

3 June 2018

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ATP6 homoplasmic mutations inhibit and destabilize the human F1F0-ATP synthase without preventing enzyme assembly and oligomerization.

3 June 2018

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

3 June 2018

1 reference

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Immunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacy.

3 June 2018

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Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection.

3 June 2018

1 reference

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Isolated late-onset cone-rod dystrophy revealing a familial neurogenic muscle weakness, ataxia, and retinitis pigmentosa syndrome with the T8993G mitochondrial mutation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4846388

The incidence of mitochondrial encephalomyopathies in childhood: clinical features and morphological, biochemical, and DNA abnormalities

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4846388

Oligomycin induces a decrease in the cellular content of a pathogenic mutation in the human mitochondrial ATPase 6 gene.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4846388

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

3 June 2018

1 reference

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Mitochondrial disease associated with the T8993G mutation of the mitochondrial ATPase 6 gene: a clinical, biochemical, and molecular study in six families

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4846388

Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4846388

Leigh syndrome and hypertrophic cardiomyopathy in an infant with a mitochondrial DNA point mutation (T8993G).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4846388

The neurotoxicity of excitatory amino acids is produced by passive chloride influx.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4846388

A complex V ATP5A1 defect causes fatal neonatal mitochondrial encephalopathy

3 June 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.13378

Mitochondrial one-carbon metabolism maintains redox balance during hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.13378

Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.13378

Medicine. A common pathway for a rare disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.13378

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27008180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mitochondrial Dysfunction and Dendritic Beading during Neuronal Toxicity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27008180

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.13378

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27008180%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27008180%20AND%20SRC:MED&resulttype=core&format=json

30 March 2020

2 references