Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes (Q28830901)

1

1 reference

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9 June 2020

Sally Darney

9

1 reference

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9 June 2020

10

Richard S Judson

1 reference

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9 June 2020

author name string

Jimmy Phuong

2

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9 June 2020

Nancy C Baker

3

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9 June 2020

Nisha S Sipes

4

1 reference

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9 June 2020

Gary R Klinefelter

5

1 reference

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9 June 2020

Matthew T Martin

6

1 reference

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9 June 2020

Keith W McLaurin

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1 reference

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9 June 2020

R Woodrow Setzer

8

1 reference

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9 June 2020

Thomas B Knudsen

11

1 reference

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9 June 2020

language of work or name

English

0 references

publication date

July 2016

0 references

number of pages

12

1 reference

Environmental Health Perspectives

inferred from page(s)

published in

1 reference

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9 June 2020

volume

124

1 reference

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9 June 2020

issue

7

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9 June 2020

page(s)

1050-1061

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26662846%20AND%20SRC:MED&resulttype=core&format=json

Antagonistic effects of a mixture of low-dose nonylphenol and di-n-butyl phthalate (monobutyl phthalate) on the Sertoli cells and serum reproductive hormones in prepubertal male rats in vitro and in vivo

9 June 2020

cites work

1 reference

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Targeting xenobiotic receptors PXR and CAR for metabolic diseases

16 March 2017

1 reference

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Male sex determination: insights into molecular mechanisms

16 March 2017

1 reference

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Neuroendocrine disruption: more than hormones are upset

16 March 2017

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Environmental chemicals in pregnant women in the United States: NHANES 2003-2004

16 March 2017

1 reference

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Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment

16 March 2017

1 reference

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

16 March 2017

1 reference

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Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

16 March 2017

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Network-based prediction of protein function

16 March 2017

1 reference

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The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat

16 March 2017

1 reference

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

16 March 2017

1 reference

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Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

BPA-induced apoptosis of rat Sertoli cells through Fas/FasL and JNKs/p38 MAPK pathways

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Role of retinoic acid receptor (RAR) signaling in post-natal male germ cell differentiation.

3 June 2018

1 reference

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Fetal programming of adult Leydig cell function by androgenic effects on stem/progenitor cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis.

3 June 2018

1 reference

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Systems toxicology: from basic research to risk assessment

3 June 2018

1 reference

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Anogenital distance and penile length in infants with hypospadias or cryptorchidism: comparison with normative data

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Using networks to measure similarity between genes: association index selection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Phthalate-induced pathology in the foetal testis involves more than decreased testosterone production

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

A critical assessment of the endocrine susceptibility of the human testis to phthalates from fetal life to adulthood

3 June 2018

1 reference

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Shorter anogenital distance correlates with undescended testis: a detailed genital anthropometric analysis in human newborns

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Hypospadias and genes related to genital tubercle and early urethral development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Diethylstilboestrol exposure does not reduce testosterone production in human fetal testis xenografts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Congenital malformations and testicular germ cell tumors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Disorders of sex development: new genes, new concepts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Assessment of male rodent fertility in general toxicology 6-month studies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms.

3 June 2018

1 reference

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Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene regulate distinct genetic networks.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

3 June 2018

1 reference

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Environmental toxicology of testicular cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Disruption of embryonic vascular development in predictive toxicology

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

3 June 2018

PPARs and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Environmental impact on vascular development predicted by high-throughput screening

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Development of the external genitalia: conserved and divergent mechanisms of appendage patterning

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

One-way inhibiting cross-talk between arylhydrocarbon receptor (AhR) and estrogen receptor (ER) signaling in primary cultures of rainbow trout hepatocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Insulin-like 3 exposure of the fetal rat gubernaculum modulates expression of genes involved in neural pathways

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Genetic pathway of external genitalia formation and molecular etiology of hypospadias

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Steroidogenesis in the fetal testis and its susceptibility to disruption by exogenous compounds

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Does a testicular dysgenesis syndrome exist?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database

3 June 2018

1 reference

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Review of the expression of peroxisome proliferator-activated receptors alpha (PPAR alpha), beta (PPAR beta), and gamma (PPAR gamma) in rodent and human development

3 June 2018

1 reference

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Diverse mechanisms of anti-androgen action: impact on male rat reproductive tract development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Toxicology. Transforming environmental health protection

3 June 2018

1 reference

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Impact of environmental pollutants on the male: effects on germ cell differentiation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Testicular dysgenesis syndrome: possible role of endocrine disrupters

3 June 2018

1 reference

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Adverse effects of environmental antiandrogens and androgens on reproductive development in mammals

3 June 2018

1 reference

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Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Testicular dysgenesis syndrome and the development and occurrence of male reproductive disorders

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Cryptorchidism: an indicator of testicular dysgenesis?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Systematic interpretation of genetic interactions using protein networks

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

PXR, CAR and drug metabolism

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Angiogenesis in the placenta

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

The rabbit as a model for reproductive and developmental toxicity studies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Genome-wide association analyses identify variants in developmental genes associated with hypospadias

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Treatment of mid-pregnant mice with KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces abnormal retinal vascular patterning in their newborn pups.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

The unique characteristics of the placental transcriptome and the hormonal metabolism enzymes in placenta.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

A computational approach to mechanistic and predictive toxicology of pesticides

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

KRN633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces intrauterine growth restriction in mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Identification of a novel androgen receptor mutation in a family with multiple components compatible with the testicular dysgenesis syndrome

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

The effects of interleukin-6 signal blockade on fertility, embryo-fetal development, and immunization in vivo.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Retinoic acid signaling regulates sonic hedgehog and bone morphogenetic protein signalings during genital tubercle development.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

The way forward in reproductive/developmental toxicity testing.

26 November 2018

1 reference

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Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Male reproductive tract malformations in rats following gestational and lactational exposure to Di(n-butyl) phthalate: an antiandrogenic mechanism?

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4937872

Differential induction of MAP kinase signalling pathways by cadmium in primary cultures of mouse embryo limb bud cells

26 November 2018

1 reference

12 December 2020

Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats

1 reference

12 December 2020

Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to Di(n-butyl) phthalate during late gestation

1 reference

12 December 2020

Role of Androgens in Fetal Testis Development and Dysgenesis

1 reference

12 December 2020

Induction of high-dose tolerance to the rat anti-mouse IL-6 receptor antibody in NZB/NZW F1 mice

1 reference

12 December 2020

Novel molecular targets associated with testicular dysgenesis induced by gestational exposure to diethylhexyl phthalate in the rat: a role for estradiol

1 reference

12 December 2020

Maternal, delivery, and perinatal characteristics associated with cryptorchidism: a population-based case-control study among births in Washington State

1 reference

12 December 2020

Identifiers

DOI

10.1289/EHP.1510385

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26662846%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26662846%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26662846%20AND%20SRC:MED&resulttype=core&format=json