Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma (Q28830095)

12

Jonathan S Weissman

0 references

Peter Walter

11

Peter Walter

0 references

Adrienne W Paton

8

Adrienne W Paton

0 references

Trever G Bivona

15

Trever G Bivona

0 references

James Paton

9

James C Paton

0 references

author name string

Amit J Sabnis

1

0 references

Christopher J Guerriero

2

0 references

Victor Olivas

3

0 references

Anin Sayana

4

0 references

Jonathan Shue

5

0 references

Jennifer Flanagan

6

0 references

Saurabh Asthana

7

0 references

Jason E Gestwicki

10

0 references

Jeffrey L Brodsky

Proceedings of the National Academy of Sciences of the United States of America

14

0 references

language of work or name

English

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publication date

9 August 2016

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published in

0 references

volume

113

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issue

32

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page(s)

9015-20

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describes a project that uses

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4987817/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Intensive Multiagent Therapy, Including Dose-Compressed Cycles of Ifosfamide/Etoposide and Vincristine/Doxorubicin/Cyclophosphamide, Irinotecan, and Radiation, in Patients With High-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group

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Refining the treatment of NSCLC according to histological and molecular subtypes

3 June 2018

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Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer

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Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

3 June 2018

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The impact of the endoplasmic reticulum protein-folding environment on cancer development

3 June 2018

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Overview of proteasome inhibitor-based anti-cancer therapies: perspective on bortezomib and second generation proteasome inhibitors versus future generation inhibitors of ubiquitin-proteasome system.

3 June 2018

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Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

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Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70

3 June 2018

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3 June 2018

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Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors

3 June 2018

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Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein

3 June 2018

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Molecular chaperone functions in protein folding and proteostasis

3 June 2018

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ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death.

3 June 2018

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A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.

3 June 2018

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Inhibiting HSP90 to treat cancer: a strategy in evolution

3 June 2018

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Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

3 June 2018

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Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation

3 June 2018

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Bortezomib as the first proteasome inhibitor anticancer drug: current status and future perspectives

3 June 2018

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Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.

3 June 2018

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The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death.

3 June 2018

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Targeting HSP70: the second potentially druggable heat shock protein and molecular chaperone?

3 June 2018

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Heat shock protein 70 (hsp70) as an emerging drug target.

3 June 2018

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Gene expression profiling for survival prediction in pediatric rhabdomyosarcomas: a report from the children's oncology group

3 June 2018

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Genomic and clinical analyses of 2p24 and 12q13-q14 amplification in alveolar rhabdomyosarcoma: a report from the Children's Oncology Group

3 June 2018

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Death by chaperone: HSP90, HSP70 or both?

3 June 2018

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Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

3 June 2018

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Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis

3 June 2018

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Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity.

3 June 2018

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Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

3 June 2018

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Fusion gene-negative alveolar rhabdomyosarcoma is clinically and molecularly indistinguishable from embryonal rhabdomyosarcoma.

3 June 2018

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Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

21 January 2018

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AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP.

21 January 2018

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2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial.

21 January 2018

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