mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1 (Q28822211)

6

0 references

Marc P M Soutar

Marc P M Soutar

5

0 references

Patrick A. Lewis

Patrick A Lewis

11

0 references

Sharon Tooze

Sharon A Tooze

9

0 references

John Anthony Hardy

8

John Hardy

0 references

Mark R Cookson

10

Mark R Cookson

0 references

Adamantios Mamais

2

Adamantios Mamais

0 references

Rina Bandopadhyay

7

Rina Bandopadhyay

0 references

author name string

Claudia Manzoni

1

0 references

Dorien A Roosen

3

0 references

Sybille Dihanich

Creative Commons Attribution 4.0 International

4

0 references

language of work or name

English

0 references

publication date

12 October 2016

0 references

published in

Scientific Reports

0 references

volume

6

0 references

page(s)

35106

0 references

copyright license

start time

12 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5059726/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Pathogenic Parkinson's disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

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GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

16 March 2017

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

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LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

16 March 2017

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

16 March 2017

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Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

16 March 2017

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

16 March 2017

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

16 March 2017

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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

16 March 2017

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Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

16 March 2017

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Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

16 March 2017

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DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

16 March 2017

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

16 March 2017

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

16 March 2017

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

16 March 2017

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Genomewide association study of leprosy

16 March 2017

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Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex

16 March 2017

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Digesting the Expanding Mechanisms of Autophagy

20 June 2018

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A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

20 June 2018

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Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

20 June 2018

1 reference

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LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

20 June 2018

1 reference

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LRRK2 autophosphorylation enhances its GTPase activity

20 June 2018

1 reference

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Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification

20 June 2018

1 reference

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Cellular processes associated with LRRK2 function and dysfunction

20 June 2018

1 reference

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Computational analysis of the LRRK2 interactome

20 June 2018

1 reference

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Assessing mammalian autophagy.

20 June 2018

1 reference

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The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

20 June 2018

1 reference

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Higher frequency of certain cancers in LRRK2 G2019S mutation carriers with Parkinson disease: a pooled analysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Regulation of the autophagic bcl-2/beclin 1 interaction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

The genetics of Parkinson's disease: progress and therapeutic implications

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Modulating macroautophagy: a neuronal perspective

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

LRRK2 inhibition attenuates microglial inflammatory responses

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Atg13 and FIP200 act independently of Ulk1 and Ulk2 in autophagy induction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

A non-canonical MEK/ERK signaling pathway regulates autophagy via regulating Beclin 1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5059726

The LRRK2 G2019S mutation is associated with Parkinson disease and concomitant non-skin cancers.

20 June 2018

1 reference

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.

21 January 2018

1 reference

LRRK2 and human disease: a complicated question or a question of complexes?

21 January 2018

1 reference

Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL.

21 January 2018

1 reference

Isolation and culture of mouse cortical astrocytes.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1038/SREP35106

1 reference

Dimensions Publication ID

3030063

1028425411

0 references

3030063

1 reference

1 reference

1 reference