Beta-2-microglobulin (Q287896)

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mammalian protein found in Homo sapiens
  • beta-2-microglobin
  • beta-2-microglobulin
  • beta chain of MHC class I molecules
  • β2 microglobulin
  • B2M
edit
Language Label Description Also known as
English
Beta-2-microglobulin
mammalian protein found in Homo sapiens
  • beta-2-microglobin
  • beta-2-microglobulin
  • beta chain of MHC class I molecules
  • β2 microglobulin
  • B2M

Statements

molecular function
protein binding
determination method
IPI
16 references
retrieved
8 April 2019
stated in
TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide
GOA
curator
UniProt
UniProt protein ID
P61769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
The crystal structure of human CD1b with a bound bacterial glycolipid
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Molecular mechanism of lipopeptide presentation by CD1a
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
The association of MHC class I proteins with the 2B4 receptor inhibits self-killing of human NK cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
MR1 presents microbial vitamin B metabolites to MAIT cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
TAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalyst
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Novel interaction between proliferating cell nuclear antigen and HLA I on the surface of tumor cells inhibits NK cell function through NKp44.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
The binding of TAPBPR and Tapasin to MHC class I is mutually exclusive
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
identical protein binding
determination method
IPI
10 references
retrieved
8 April 2019
stated in
D-strand perturbation and amyloid propensity in beta-2 microglobulin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic  2-microglobulin variant
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
3D structure of amyloid protofilaments of beta2-microglobulin fragment probed by solid-state NMR.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
A recurrent D-strand association interface is observed in β-2 microglobulin oligomers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
A regulatable switch mediates self-association in an immunoglobulin fold
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Protein-induced photophysical changes to the amyloid indicator dye thioflavin T
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
retrieved
8 April 2019
stated in
Fibrillogenic propensity of the GroEL apical domain: a Janus-faced minichaperone
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61769
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE B2M 201891 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

Reaxys registry number
1416971
0 references
PDB structure ID
 
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