Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration (Q28649438)

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English	Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration	scientific article

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scholarly article

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Europe PubMed Central

Concise review: modeling multiple sclerosis with stem cell biological platforms: toward functional validation of cellular and molecular phenotypes in inflammation-induced neurodegeneration (English)

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multiple sclerosis

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neurodegeneration

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based on heuristic

inferred from title

10

object named as

Jaime Imitola

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author name string

Joshua C Orack

1

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Michela Deleidi

2

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David Pitt

3

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Kedar Mahajan

4

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Jacqueline A Nicholas

5

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Aaron L Boster

6

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Michael K Racke

7

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Manuel Comabella

8

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Fumihiro Watanabe

9

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language of work or name

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publication date

March 2015

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Stem Cells Translational Medicine

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4

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3

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252-60

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Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

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17 March 2017

Multiplex genome engineering using CRISPR/Cas systems

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17 March 2017

Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research

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17 March 2017

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

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17 March 2017

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

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17 March 2017

Modelling schizophrenia using human induced pluripotent stem cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

17 March 2017

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

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17 March 2017

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

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17 March 2017

Breaking the code of DNA binding specificity of TAL-type III effectors

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17 March 2017

Reprogramming of human somatic cells to pluripotency with defined factors

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17 March 2017

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

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17 March 2017

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

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17 March 2017

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

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17 March 2017

Cerebral organoids model human brain development and microcephaly

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23 March 2017

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

7 April 2017

Efficient generation of myelinating oligodendrocytes from primary progressive multiple sclerosis patients by induced pluripotent stem cells.

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3 June 2018

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation.

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3 June 2018

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.

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3 June 2018

Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes

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3 June 2018

Relapsing and progressive forms of multiple sclerosis: insights from pathology

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3 June 2018

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

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3 June 2018

Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons

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3 June 2018

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

A regenerative approach to the treatment of multiple sclerosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Disease-specific molecular events in cortical multiple sclerosis lesions.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Genetic insights in Alzheimer's disease

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3 June 2018

Induced pluripotent stem cells: the new patient?

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Erosion of dosage compensation impacts human iPSC disease modeling

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3 June 2018

Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Neural differentiation of patient specific iPS cells as a novel approach to study the pathophysiology of multiple sclerosis.

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3 June 2018

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

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3 June 2018

Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases

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3 June 2018

Constructing and deconstructing stem cell models of neurological disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Development of histocompatible primate-induced pluripotent stem cells for neural transplantation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Reversible neural stem cell niche dysfunction in a model of multiple sclerosis.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Copy number variation and selection during reprogramming to pluripotency

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Edgetic perturbation models of human inherited disorders

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3 June 2018

Persistent inflammation alters the function of the endogenous brain stem cell compartment

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4339849

3 June 2018

Insights into the molecular pathogenesis of progression in multiple sclerosis: potential implications for future therapies

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3 June 2018

Cortical demyelination and diffuse white matter injury in multiple sclerosis.

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https://api.crossref.org/works/10.5966%2FSCTM.2014-0133

21 January 2018

iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.

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https://api.crossref.org/works/10.5966%2FSCTM.2014-0133

21 January 2018

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

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https://api.crossref.org/works/10.5966%2FSCTM.2014-0133

21 January 2018

Characterization of human monocyte-derived microglia-like cells.

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https://api.crossref.org/works/10.5966%2FSCTM.2014-0133

21 January 2018

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis

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https://api.crossref.org/works/10.5966%2FSCTM.2014-0133

21 January 2018

iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF.

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https://api.crossref.org/works/10.5966%2FSCTM.2014-0133

21 January 2018

EAE: imperfect but useful models of multiple sclerosis

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https://pubmed.ncbi.nlm.nih.gov/25593207

12 December 2020

based on heuristic

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Targeted genome editing in pluripotent stem cells using zinc-finger nucleases

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https://pubmed.ncbi.nlm.nih.gov/25593207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate excitotoxicity in a model of multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25593207

12 December 2020

based on heuristic

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Persistent activation of microglia is associated with neuronal dysfunction of callosal projecting pathways and multiple sclerosis-like lesions in relapsing--remitting experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/25593207

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.5966/SCTM.2014-0133

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