Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity (Q28616012)

2

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3 February 2017

J. Carew

3

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3 February 2017

J. P. Viola

4

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3 February 2017

C. Luo

5

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3 February 2017

A. Rao

Journal of Biological Chemistry

7

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3 February 2017

language of work or name

English

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publication date

3 May 1996

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3 February 2017

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3 February 2017

271

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3 February 2017

10884–10891

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3 February 2017

18

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3 February 2017

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Isolation of the cyclosporin-sensitive T cell transcription factor NFATp

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Signal transmission between the plasma membrane and nucleus of T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Transcriptional regulation of the IL-2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

NF-AT components define a family of transcription factors targeted in T-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Calcineurin mediates human tumor necrosis factor alpha gene induction in stimulated T and B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Activation and expression of the nuclear factors of activated T cells, NFATp and NFATc, in human natural killer cells: regulation upon CD16 ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Cyclosporin-A sensitive induction of NF-AT in murine B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Fc epsilon RI-mediated induction of nuclear factor of activated T-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

The mechanism of action of cyclosporin A and FK506

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Signal integration at the level of protein kinases, protein phosphatases and their substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

On target with a new mechanism for the regulation of protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Association of protein kinase A and protein phosphatase 2B with a common anchoring protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

The proliferation of MAP kinase signaling pathways in yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Photocell measurements of rat motor activity. A contribution to sensitivity and variation in behavioral observations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Regulation of interleukin 2 gene expression by CD28 costimulation in mouse T-cell clones: both nuclear and cytoplasmic RNAs are regulated with complex kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Ionomycin activates electrogenic Ca2+ influx in rat thymic lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Neuronal Ca2+/calmodulin-dependent protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884

Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.18.10884