The role of the stress-activated protein kinase (SAPK/JNK) signaling pathway in radiation-induced apoptosis (Q28611462)

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S. F. Zerp

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W. J. van Blitterswijk

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3 February 2017

The Klaas Breur Lecture. Radiation, hypoxia and genetic stimulation: implications for future therapies

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7 January 2021

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

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7 January 2021

The molecular regulation of apoptosis and implications for radiation oncology

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7 January 2021

Induction of apoptosis by the transcription factor c-Jun

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

CD28 signals through acidic sphingomyelinase

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7 January 2021

The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy

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7 January 2021

c-Jun NH2-terminal kinase regulation of the apoptotic response of small cell lung cancer cells to ultraviolet radiation

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7 January 2021

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

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7 January 2021

Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis

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7 January 2021

The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation

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7 January 2021

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

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7 January 2021

Caspases: the executioners of apoptosis

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7 January 2021

Of what use is molecular biology to the practicing radiation oncologist?

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7 January 2021

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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7 January 2021

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

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7 January 2021

Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis

1 reference

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7 January 2021

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Radiation-induced apoptosis: relevance to radiotherapy

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7 January 2021

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

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7 January 2021

Naturally occurring (programmed) and radiation-induced apoptosis are associated with selective c-Jun expression in the developing rat brain

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7 January 2021

Apoptosis in cancer therapy: crossing the threshold

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7 January 2021

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

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7 January 2021

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Transcription factor ATF2 regulation by the JNK signal transduction pathway

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7 January 2021

Selective interaction of JNK protein kinase isoforms with transcription factors

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7 January 2021

Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity

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7 January 2021

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

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7 January 2021

A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death

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7 January 2021

Ceramide induces apoptosis in PC12 cells

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

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7 January 2021

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

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7 January 2021

Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases

1 reference

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7 January 2021

Stereospecific induction of apoptosis in U937 cells by N-octanoyl-sphingosine stereoisomers and N-octyl-sphingosine. The ceramide amide group is not required for apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Activation of Raf by ionizing radiation

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Apoptosis. Its significance in cancer and cancer therapy

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7 January 2021

Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents

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7 January 2021

HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

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7 January 2021

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

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7 January 2021

Sphingomyelin and derivatives as cellular signals

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7 January 2021

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

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7 January 2021

The stress-activated protein kinase subfamily of c-Jun kinases

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7 January 2021

Radiosensitivity and oxidative signalling in ataxia telangiectasia: an update.

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7 January 2021

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

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7 January 2021

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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7 January 2021

Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta

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7 January 2021

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases

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7 January 2021

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

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7 January 2021

Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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7 January 2021

Apoptosis by death factor

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7 January 2021

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

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7 January 2021

Phosphorylation of c-jun mediated by MAP kinases.

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7 January 2021

Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation

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7 January 2021

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

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7 January 2021

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

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7 January 2021

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Signal transduction by tumor necrosis factor mediated by JNK protein kinases

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7 January 2021

Apoptosis in the pathogenesis and treatment of disease

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7 January 2021

Activation of Pyk2 by stress signals and coupling with JNK signaling pathway

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Ceramide activates the stress-activated protein kinases

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Integration of MAP kinase signal transduction pathways at the serum response element

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells

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7 January 2021

Cell death: the significance of apoptosis

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7 January 2021

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

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7 January 2021

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

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https://api.crossref.org/works/10.1016%2FS0167-8140%2898%2900007-3

7 January 2021

Daxx, a novel Fas-binding protein that activates JNK and apoptosis

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7 January 2021

Molecular aspects of cellular responses to radiotherapy

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7 January 2021

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme

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7 January 2021

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

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7 January 2021

Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1.

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7 January 2021