Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system (Q28594530)

Helt bHLH transcription factor

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

nervous system

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author name string

Tomoya Nakatani

1

1 reference

31 January 2017

Eri Mizuhara

2

1 reference

31 January 2017

Yasuko Minaki

3

1 reference

31 January 2017

Yoshimasa Sakamoto

4

1 reference

31 January 2017

Yuichi Ono

Journal of Biological Chemistry

5

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31 January 2017

language of work or name

English

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publication date

16 April 2004

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31 January 2017

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31 January 2017

279

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31 January 2017

16356–16367

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31 January 2017

16

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31 January 2017

bHLH transcription factors and mammalian neuronal differentiation

1 reference

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Basic helix-loop-helix genes in neural development

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Two mammalian helix-loop-helix factors structurally related to Drosophila hairy and Enhancer of split

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Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

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1 reference

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Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression

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1 reference

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HES-1 repression of differentiation and proliferation in PC12 cells: role for the helix 3-helix 4 domain in transcription repression

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1 reference

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Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors

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1 reference

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The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain

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1 reference

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Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif

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Signalling downstream of activated mammalian Notch

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Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

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1 reference

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The Notch-Hes pathway in mammalian neural development

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Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms

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HERP, a new primary target of Notch regulated by ligand binding

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1 reference

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HERP1 is a cell type-specific primary target of Notch

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1 reference

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Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

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1 reference

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Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells.

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1 reference

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Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain

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1 reference

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Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway

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1 reference

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SHARPs: mammalian enhancer-of-split- and hairy-related proteins coupled to neuronal stimulation.

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TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3

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Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac.

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Identification of a nuclear domain with deacetylase activity.

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Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors

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Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

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Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop

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Signals from the ventral midline and isthmus regulate the development of Brn3.0-expressing neurons in the midbrain

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The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord

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Target specificities of Drosophila enhancer of split basic helix-loop-helix proteins

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