PDE5 is converted to an activated state upon cGMP binding to the GAF A domain (Q28593893)

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

GOA release 2020-03-11

1

Sergei D. Rybalkin

1 reference

31 January 2017

5

Joseph A. Beavo

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31 January 2017

2

Irina G. Rybalkina

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31 January 2017

Masami Shimizu-Albergine

series ordinal

3

object named as

Masami Shimizu-Albergine

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31 January 2017

Xiao-Bo Tang

4

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31 January 2017

language of work or name

English

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publication date

3 February 2003

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31 January 2017

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31 January 2017

22

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31 January 2017

3

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31 January 2017

469–478

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31 January 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Allosteric activation of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) by cGMP.

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Tadalafil (Cialis) for men with erectile dysfunction.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Regulatory potential, phyletic distribution and evolution of ancient, intracellular small-molecule-binding domains.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

The GAF domain: an evolutionary link between diverse phototransducing proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Sequence homology and structure--function studies of the bovine cyclic-GMP-stimulated and retinal phosphodiesterases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Regulation of cGMP-specific phosphodiesterase (PDE5) phosphorylation in smooth muscle cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Molecular organization of bovine rod cGMP-phosphodiesterase 6.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=140735

Phosphorylation of phosphodiesterase-5 by cyclic nucleotide-dependent protein kinase alters its catalytic and allosteric cGMP-binding activities

27 November 2018

1 reference

12 December 2020

ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells

1 reference

12 December 2020

Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases

1 reference

12 December 2020

Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes

1 reference

12 December 2020

Cyclic GMP-specific, high affinity, noncatalytic binding sites on light-activated phosphodiesterase

1 reference

12 December 2020

Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues

1 reference

12 December 2020

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase

1 reference

12 December 2020

Mechanisms of NO/cGMP-dependent vasorelaxation

1 reference

12 December 2020

Mechanism of transducin activation of frog rod photoreceptor phosphodiesterase. Allosteric interactiona between the inhibitory gamma subunit and the noncatalytic cGMP-binding sites

1 reference

12 December 2020

Intercellular action of nitric oxide increases cGMP in cerebellar Purkinje cells

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/CDG051

1 reference

4927950

4927950

1 reference

1 reference

1 reference