Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling (Q28589839)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19666503%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19666503%20AND%20SRC:MED&resulttype=core&format=json

Kinesin-like protein KIF7

5 February 2020

main subject

1 reference

GOA release 2020-03-11

author

Kathryn V. Anderson

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19666503%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Mu He

2

2 references

31 January 2017

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5 February 2020

Karel F Liem

1

1 reference

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5 February 2020

Polloneal Jymmiel R Ocbina

3

1 reference

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5 February 2020

language of work or name

English

0 references

publication date

29 July 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19666503%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

5 February 2020

published in

2 references

31 January 2017

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5 February 2020

volume

106

2 references

31 January 2017

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5 February 2020

page(s)

13377-13382

1 reference

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5 February 2020

issue

32

2 references

31 January 2017

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The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development

5 February 2020

cites work

1 reference

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The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling

17 March 2017

1 reference

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Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

17 March 2017

1 reference

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Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4

17 March 2017

1 reference

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THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

17 March 2017

1 reference

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Cilia and developmental signaling

17 March 2017

1 reference

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The graded response to Sonic Hedgehog depends on cilia architecture

17 March 2017

1 reference

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Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway

17 March 2017

1 reference

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Divergence of hedgehog signal transduction mechanism between Drosophila and mammals

17 March 2017

1 reference

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Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

17 March 2017

1 reference

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Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function

17 March 2017

1 reference

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Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

17 March 2017

1 reference

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Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused

17 March 2017

1 reference

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Vertebrate Smoothened functions at the primary cilium

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

The zebrafish mutants dre, uki, and lep encode negative regulators of the hedgehog signaling pathway

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Analysis of the kinesin superfamily: insights into structure and function

17 March 2017

1 reference

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Cilia and Hedgehog responsiveness in the mouse

17 March 2017

1 reference

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Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Mice deficient in the fused homolog do not exhibit phenotypes indicative of perturbed hedgehog signaling during embryonic development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Analysis of mouse embryonic patterning and morphogenesis by forward genetics

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Hedgehog signalling in the mouse requires intraflagellar transport proteins

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Small molecule modulation of Smoothened activity

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Altered neural cell fates and medulloblastoma in mouse patched mutants

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Skeletal and CNS defects in Presenilin-1-deficient mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

A mouse model of greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Patched1 regulates hedgehog signaling at the primary cilium

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Directed differentiation of embryonic stem cells into motor neurons

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

The primary cilium at the crossroads of mammalian hedgehog signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Hedgehog signaling in development and cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Centrosome control of the cell cycle

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

The extracellular domain of Smoothened regulates ciliary localization and is required for high-level Hh signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2726420

27 November 2018

Identifiers

DOI

10.1073/PNAS.0906944106

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19666503%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

ADS bibcode

2009PNAS..10613377L

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19666503%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

2 references