The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane (Q28587156)

Lipopolysaccharide binding protein

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

CD14 antigen

1 reference

GOA release 2020-03-11

Yukari Fujimoto

5

0 references

author name string

Natsuko Tanimura

1

1 reference

31 January 2017

Shin-Ichiroh Saitoh

2

1 reference

31 January 2017

Umeharu Ohto

3

1 reference

31 January 2017

Sachiko Akashi-Takamura

4

1 reference

31 January 2017

Koichi Fukase

6

1 reference

31 January 2017

Toshiyuki Shimizu

7

1 reference

31 January 2017

Kensuke Miyake

CD14 is required for MyD88-independent LPS signaling.

8

1 reference

31 January 2017

language of work or name

1 reference

1 June 2014

1 reference

31 January 2017

International Immunology

1 reference

31 January 2017

26

1 reference

31 January 2017

6

1 reference

31 January 2017

307–314

1 reference

31 January 2017

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Human TLR4 polymorphism D299G/T399I alters TLR4/MD-2 conformation and response to a weak ligand monophosphoryl lipid A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Divergent response to LPS and bacteria in CD14-deficient murine macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

Function and dysfunction of the PI system in membrane trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071

CD14-independent responses induced by a synthetic lipid A mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FINTIMM%2FDXT071