Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models (Q28572282)

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31 January 2017

Mauro Dal Canto

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31 January 2017

Krystyna Wozniak

5

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31 January 2017

Camilo Rojas

7

1 reference

31 January 2017

Takashi Tsukamoto

8

1 reference

31 January 2017

Richard J. Miller

10

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31 January 2017

Anna Liza Monti

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31 January 2017

Raymond P. Roos

Proceedings of the National Academy of Sciences of the United States of America

12

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31 January 2017

language of work or name

English

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publication date

5 August 2003

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31 January 2017

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31 January 2017

100

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31 January 2017

9554–9559

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31 January 2017

16

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31 January 2017

Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Ca(2+)-permeable AMPA receptors and selective vulnerability of motor neurons

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Riluzole preserves motor function in a transgenic model of familial amyotrophic lateral sclerosis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Reductions in acidic amino acids andN-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

CSF and plasma amino acid levels in motor neuron disease: elevation of CSF glutamate in a subset of patients.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Tardive decrease of astrocytic glutamate transporter protein in transgenic mice with ALS-linked mutant SOD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Increases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Laboratory standards in the assessment of the quality of care.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

N-acetylaspartylglutamate catabolism is achieved by an enzyme on the cell surface of neurons and glia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Modulation of behavioral sensitization to cocaine by NAALADase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADASE).

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Neuroprotection mediated by glutamate carboxypeptidase II (NAALADase) inhibition requires TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Mechanisms for clearance of released N-acetylaspartylglutamate in crayfish nerve fibers: implications for axon-glia signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Glutamate potentiates the toxicity of mutant Cu/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=170956

A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group

27 November 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Selective vulnerability of spinal cord motor neurons to non-NMDA toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1530168100

Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: molecular mechanisms of neuronal death and protection

21 January 2018

1 reference

12 December 2020

Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta

1 reference

12 December 2020

AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability

1 reference

12 December 2020

Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease

1 reference

12 December 2020