Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells (Q28571575)

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31 January 2017

M. Vigny

3

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31 January 2017

R. H. Palmer

4

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31 January 2017

B. Hallberg

Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications

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31 January 2017

language of work or name

English

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publication date

13 May 2010

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31 January 2017

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31 January 2017

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31 January 2017

2817–2830

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31 January 2017

19

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31 January 2017

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ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

21 April 2017

1 reference

Activating mutations in ALK provide a therapeutic target in neuroblastoma

21 April 2017

1 reference

Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

21 April 2017

1 reference

Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system

21 April 2017

1 reference

Leukocyte tyrosine kinase functions in pigment cell development

21 April 2017

1 reference

Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation in vivo

21 April 2017

1 reference

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

21 April 2017

1 reference

Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

21 April 2017

1 reference

Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines

21 April 2017

1 reference

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

21 April 2017

1 reference

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

21 April 2017

1 reference

Identification of ALK as a major familial neuroblastoma predisposition gene

21 April 2017

1 reference

Anaplastic lymphoma kinase: signalling in development and disease

21 April 2017

1 reference

Specificity in Ras and Rap signaling

21 April 2017

1 reference

Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway

21 April 2017

1 reference

Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin

21 April 2017

1 reference

Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types

21 April 2017

1 reference

Downregulation of Rap1GAP contributes to Ras transformation

21 April 2017

1 reference

The guanine nucleotide exchange factor C3G is necessary for the formation of focal adhesions and vascular maturation

21 April 2017

1 reference

C3G regulates the size of the cerebral cortex neural precursor population

21 April 2017

1 reference

cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

21 April 2017

1 reference

DOCK4, a GTPase activator, is disrupted during tumorigenesis

21 April 2017

1 reference

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Mitogenic and oncogenic properties of the small G protein Rap1b

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Activation of Rap1 promotes prostate cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Rap1 signalling: adhering to new models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Oncogenic mutations of ALK kinase in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

C3G is tyrosine-phosphorylated after integrin-mediated cell adhesion in normal but not in Bcr/Abl expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Rapid Ca2+-mediated activation of Rap1 in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Identity with the mitogen-activated MAP kinase of fibroblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Early events in neurotrophin signalling via Trk and p75 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

C3G-mediated suppression of oncogene-induced focus formation in fibroblasts involves inhibition of ERK activation, cyclin A expression and alterations of anchorage-independent growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Mutation in RAP1 is a rare event in myelodysplastic syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Exoenzyme S shows selective ADP-ribosylation and GTPase-activating protein (GAP) activities towards small GTPases in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Expression of the ALK tyrosine kinase gene in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

An SCF-like ubiquitin ligase complex that controls presynaptic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Rap1-suppressed tumorigenesis is concomitant with the interference in ras effector signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Mutation analysis of RAP1 gene in papillary thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Biological role of anaplastic lymphoma kinase in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

A ligand-inducible epidermal growth factor receptor/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

The guanine nucleotide exchange factor, C3G regulates differentiation and survival of human neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

On the mitogenic properties of Rap1b: cAMP-induced G(1)/S entry requires activated and phosphorylated Rap1b

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Drosophila Anaplastic Lymphoma Kinase regulates Dpp signalling in the developing embryonic gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Does Rap1 deserve a bad Rap?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways(mili(Alk)) as receptor for Jeb signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Characterization of the expression of the ALK receptor tyrosine kinase in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

C3G regulates cortical neuron migration, preplate splitting and radial glial cell attachment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

Nerve growth factor activates persistent Rap1 signaling in endosomes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27

HRap1B-retro: a novel human processed rap1B gene blurs the picture?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.27