Protein kinase C, zeta (Q28563293)

Protein kinase-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Protein kinase C, PB1 domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Protein kinase, C-terminal domain, protein family

1 reference

PB1 domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

AGC-kinase, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38

protein kinase activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

protein serine/threonine kinase activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

8 references

14 February 2019

Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Molecular cloning and characterization of a novel protein kinase C-interacting protein with structural motifs related to RBCC family proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Regulation of the expression of prostate apoptosis response protein 4 (Par-4) in rat granulosa cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Cloning, expression and characterization of an A6-related protein

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09217&geneProductId=UniProtKB:P09217

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09217&geneProductId=UniProtKB:P09217

1 January 2018

An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09217&geneProductId=UniProtKB:P09217

potassium channel regulator activity

1 reference

14 February 2019

Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

protein kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

protein domain specific binding

IPI

1 reference

1 January 2018

An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09217&geneProductId=UniProtKB:P09217

ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy

IPI

phospholipase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

14-3-3 protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

2 references

1 reference

14 February 2019

Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

microtubule organizing center

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Selective changes in protein kinase C isoforms and phosphorylation of endogenous substrate proteins in rat cerebral cortex during pre- and postnatal ethanol exposure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

2 references

bicellular tight junction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

Cellular and subcellular localization of PKMζ.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

apical plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

protein-containing complex

1 reference

1 January 2018

An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P09217&geneProductId=UniProtKB:P09217

myelin sheath abaxonal region

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

intracellular membrane-bounded organelle

1 reference

14 February 2019

Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

Ceramide recruits and activates protein kinase C zeta (PKC zeta) within structured membrane microdomains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

perinuclear region of cytoplasm

1 reference

14 February 2019

Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

Schaffer collateral - CA1 synapse

EXP

microtubule cytoskeleton organization

glutamatergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

positive regulation of cell-matrix adhesion

1 reference

14 February 2019

ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

protein phosphorylation

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

inflammatory response

1 reference

14 February 2019

1 reference

14 February 2019

PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

cell surface receptor signaling pathway

1 reference

14 February 2019

Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

positive regulation of cell population proliferation

1 reference

14 February 2019

Essential role of PKC-zeta in normal and angiotensin II-accelerated neointimal growth after vascular injury

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

1 reference

14 February 2019

An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

peptidyl-serine phosphorylation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase in vitro at Ser-80 and Ser-91

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

establishment of cell polarity

IBA

1 reference

14 February 2019

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

negative regulation of protein-containing complex assembly

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

activation of phospholipase D activity

1 reference

14 February 2019

ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

activation of protein kinase B activity

1 reference

14 February 2019

Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

cellular response to insulin stimulus

1 reference

14 February 2019

Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

intracellular signal transduction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

negative regulation of apoptotic process

IBA

1 reference

14 February 2019

PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

negative regulation of insulin receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

positive regulation of insulin receptor signaling pathway

1 reference

14 February 2019

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

vesicle transport along microtubule

1 reference

14 February 2019

PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

negative regulation of peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

positive regulation of synaptic transmission

1 reference

14 February 2019

Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

positive regulation of NF-kappaB transcription factor activity

1 reference

14 February 2019

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

positive regulation of protein transport

1 reference

14 February 2019

Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

negative regulation of hydrolase activity

1 reference

14 February 2019

PKCzeta protects against UV-C-induced apoptosis by inhibiting acid sphingomyelinase-dependent ceramide production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

Tumor necrosis factor alpha and ceramide depolarise the resting membrane potential of thyroid FRTL-5 cells via a protein kinase Czeta-dependent regulation of K+ channels

membrane depolarization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

membrane hyperpolarization

1 reference

14 February 2019

Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

Protein kinase Mzeta is necessary and sufficient for LTP maintenance

long-term potentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

positive regulation of ERK1 and ERK2 cascade

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

protein kinase C signaling

1 reference

14 February 2019

The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

protein localization to plasma membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

EXP

neuron projection extension

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

positive regulation of excitatory postsynaptic potential

1 reference

14 February 2019

Protein kinase Mzeta is necessary and sufficient for LTP maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09217

protein kinase, C-terminal

has part(s)

1 reference

AGC-kinase, C-terminal

1 reference

serine/threonine-protein kinase, active site

1 reference

protein kinase, ATP binding site

1 reference

PB1 domain

1 reference

diacylglycerol/phorbol-ester binding

1 reference

protein kinase domain

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

Protein kinase C, PB1 domain

1 reference